Ventricular arrhythmias in ischemic cardiomyopathy—New avenues for mechanism-guided treatment

M Amoni, E Dries, S Ingelaere, D Vermoortele… - Cells, 2021 - mdpi.com
Ischemic heart disease is the most common cause of lethal ventricular arrhythmias and
sudden cardiac death (SCD). In patients who are at high risk after myocardial infarction …

Creation and application of virtual patient cohorts of heart models

SA Niederer, Y Aboelkassem… - … of the Royal …, 2020 - royalsocietypublishing.org
Patient-specific cardiac models are now being used to guide therapies. The increased use
of patient-specific cardiac simulations in clinical care will give rise to the development of …

Evaluating computational efforts and physiological resolution of mathematical models of cardiac tissue

KH Jæger, JD Trotter, X Cai, H Arevalo, A Tveito - Scientific Reports, 2024 - nature.com
Computational techniques have significantly advanced our understanding of cardiac
electrophysiology, yet they have predominantly concentrated on averaged models that do …

The association of cannabis use and cardiac dysrhythmias: a systematic review

JR Richards, E Blohm, KA Toles, AF Jarman… - Clinical …, 2020 - Taylor & Francis
Introduction: Cannabis use results in elevation of heart rate and blood pressure immediately
after use, primarily due to sympathetic nervous system stimulation and parasympathetic …

Uncertainty quantification and sensitivity analysis of left ventricular function during the full cardiac cycle

JO Campos, J Sundnes… - … Transactions of the …, 2020 - royalsocietypublishing.org
Patient-specific computer simulations can be a powerful tool in clinical applications, helping
in diagnostics and the development of new treatments. However, its practical use depends …

An audit of uncertainty in multi-scale cardiac electrophysiology models

RH Clayton, Y Aboelkassem… - … of the Royal …, 2020 - royalsocietypublishing.org
Models of electrical activation and recovery in cardiac cells and tissue have become
valuable research tools, and are beginning to be used in safety-critical applications …

A smoothed boundary bidomain model for cardiac simulations in anatomically detailed geometries

N Biasi, P Seghetti, M Mercati, A Tognetti - PloS one, 2023 - journals.plos.org
This manuscript presents a novel finite difference method to solve cardiac bidomain
equations in anatomical models of the heart. The proposed method employs a smoothed …

Factors promoting conduction slowing as substrates for block and reentry in infarcted hearts

FO Campos, J Whitaker, R Neji, S Roujol, M O'Neill… - Biophysical …, 2019 - cell.com
The development of effective and safe therapies for scar-related ventricular tachycardias
requires a detailed understanding of the mechanisms underlying the conduction block that …

[HTML][HTML] Complex-order fractional diffusion in reaction-diffusion systems

A Bueno-Orovio, K Burrage - Communications in Nonlinear Science and …, 2023 - Elsevier
Fractional differential equations have become a fundamental modelling approach for
understanding and simulating the many aspects of non-locality and spatial heterogeneity of …

A 3D transmurally heterogeneous computational model of the Brugada Syndrome phenotype

P Seghetti, N Biasi, A Tognetti - IEEE Access, 2023 - ieeexplore.ieee.org
In this work, we present a computational study of the Brugada Syndrome (BrS) phenotype
aimed at investigating the main factors contributing to the development of arrhythmias. We …