S-adenosylmethionine: From the discovery of its inhibition of tumorigenesis to its use as a therapeutic agent

RM Pascale, MM Simile, DF Calvisi, CF Feo, F Feo - Cells, 2022 - mdpi.com
Alterations of methionine cycle in steatohepatitis, cirrhosis, and hepatocellular carcinoma
induce MAT1A decrease and MAT2A increase expressions with the consequent decrease of …

Gonadotropin‐releasing hormone: GnRH receptor signaling in extrapituitary tissues

LWT Cheung, AST Wong - The FEBS journal, 2008 - Wiley Online Library
Gonadotropin‐releasing hormone (GnRH) has historically been known as a pituitary
hormone; however, in the past few years, interest has been raised in locally produced …

Differential reelin-induced enhancement of NMDA and AMPA receptor activity in the adult hippocampus

S Qiu, LF Zhao, KM Korwek… - Journal of Neuroscience, 2006 - Soc Neuroscience
The developmental lamination of the hippocampus and other cortical structures requires a
signaling cascade initiated by reelin and its receptors, apoER2 (apolipoprotein E receptor 2) …

Apelin, an endogenous neuronal peptide, protects hippocampal neurons against excitotoxic injury

LA O'Donnell, A Agrawal, P Sabnekar… - Journal of …, 2007 - Wiley Online Library
Several G protein‐coupled receptors (GPCRs) mediate neuronal cell migration and survival
upon activation by their native peptide ligands but activate death‐signaling pathways when …

G protein‐coupled receptor‐induced Akt activity in cellular proliferation and apoptosis

DC New, K Wu, AWS Kwok, YH Wong - The FEBS journal, 2007 - Wiley Online Library
Akt (also known as protein kinase B) plays an integral role in many intracellular signaling
pathways activated by a diverse array of extracellular signals that target several different …

EGFR-mediated expression of aquaporin-3 is involved in human skin fibroblast migration

C Cao, Y Sun, S Healey, Z Bi, G Hu, S Wan… - Biochemical …, 2006 - portlandpress.com
AQP3 (aquaporin-3), known as an integral membrane channel in epidermal keratinocytes,
facilitates water and glycerol movement into and out of the skin. Here, we demonstrate that …

Curcumin attenuates EGF-induced AQP3 up-regulation and cell migration in human ovarian cancer cells

C Ji, C Cao, S Lu, R Kivlin, A Amaral, N Kouttab… - Cancer chemotherapy …, 2008 - Springer
Objective Aquaporin (AQP) water channels are expressed in high-grade tumor cells of
different tissue origins. Based on the involvement of AQPs in angiogenesis and cell …

Equol-stimulated mitochondrial reactive oxygen species activate endothelial nitric oxide synthase and redox signaling in endothelial cells: roles for F-actin and GPR30

DJ Rowlands, S Chapple, RCM Siow, GE Mann - Hypertension, 2011 - Am Heart Assoc
We reported previously that dietary isoflavones modulate arterial blood pressure in vivo and
that the daidzein metabolite equol rapidly activates endothelial NO synthase (eNOS) via Akt …

Signal transduction in multifactorial neuroendocrine control of gonadotropin secretion and synthesis in teleosts—studies on the goldfish model

JP Chang, JD Johnson, GR Sawisky, CL Grey… - General and …, 2009 - Elsevier
In teleosts, gonadotropin (GTH) secretion and synthesis is controlled by multiple
neuroendocrine factors from the hypothalamus, pituitary and peripheral sources. Pituitary …

[HTML][HTML] Bovine sperm acrosome reaction induced by G protein-coupled receptor agonists is mediated by epidermal growth factor receptor transactivation

N Etkovitz, Y Tirosh, R Chazan, Y Jaldety, L Daniel… - Developmental …, 2009 - Elsevier
We have previously demonstrated the presence of active epidermal growth factor receptor
(EGFR) and its involvement in sperm capacitation and the acrosome reaction; however, the …