Autophagy and apoptosis cascade: which is more prominent in neuronal death?

R Gupta, RK Ambasta, P Kumar - Cellular and molecular life sciences, 2021 - Springer
Autophagy and apoptosis are two crucial self-destructive processes that maintain cellular
homeostasis, which are characterized by their morphology and regulated through signal …

Synaptic elimination in neurological disorders

PL Cardozo, IBQ de Lima, EMA Maciel… - Current …, 2019 - benthamdirect.com
Synapses are well known as the main structures responsible for transmitting information
through the release and recognition of neurotransmitters by pre-and post-synaptic neurons …

Zinc ion rapidly induces toxic, off-pathway amyloid-β oligomers distinct from amyloid-β derived diffusible ligands in Alzheimer's disease

MC Lee, WC Yu, YH Shih, CY Chen, ZH Guo… - Scientific reports, 2018 - nature.com
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the elderly.
Zinc (Zn) ion interacts with the pathogenic hallmark, amyloid-β (Aβ), and is enriched in …

Targeting GSK3 signaling as a potential therapy of neurodegenerative diseases and aging

P Duda, J Wiśniewski, T Wójtowicz… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: Glycogen synthase kinase 3 (GSK3) is at the center of cellular signaling and
controls various aspects of brain functions, including development of the nervous system …

[HTML][HTML] Neuroprotective effect of caffeic acid phenethyl ester in a mouse model of Alzheimer's disease involves Nrf2/HO-1 pathway

F Morroni, G Sita, A Graziosi, E Turrini… - Aging and …, 2018 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a progressive pathology, where dementia symptoms gradually
worsen over a number of years. The hallmarks of AD, such as amyloid β-peptide (Aβ) in …

Targeted delivery via albumin corona nanocomplex to renal tubules to alleviate acute kidney injury

S Qin, B Wu, T Gong, ZR Zhang, Y Fu - Journal of Controlled Release, 2022 - Elsevier
Renal tubular epithelial cell (RTEC) is a critical target cell for the treatment of acute kidney
injury (AKI). Despite various RTEC targeting strategies using ligand modified nanoparticles …

Synaptic dysfunction in Alzheimer's disease: Aβ, tau, and epigenetic alterations

K Li, Q Wei, FF Liu, F Hu, A Xie, LQ Zhu, D Liu - Molecular neurobiology, 2018 - Springer
Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized in the
early stages by loss of learning and memory. However, the mechanism underlying these …

Early life stress and epigenetics in late-onset Alzheimer's dementia: a systematic review

E Lemche - Current genomics, 2018 - ingentaconnect.com
Involvement of life stress in Late-Onset Alzheimer's Disease (LOAD) has been evinced in
longitudinal cohort epidemiological studies, and endocrinologic evidence suggests …

Fluoxetine and Vortioxetine Reverse Depressive-Like Phenotype and Memory Deficits Induced by Aβ1-42 Oligomers in Mice: A Key Role of Transforming Growth …

SA Torrisi, F Geraci, MR Tropea, M Grasso… - Frontiers in …, 2019 - frontiersin.org
Depression is a risk factor for the development of Alzheimer's disease (AD), and the
presence of depressive symptoms significantly increases the conversion of mild cognitive …

Common protective strategies in neurodegenerative disease: focusing on risk factors to target the cellular redox system

P Hrelia, G Sita, M Ziche, E Ristori… - Oxidative Medicine …, 2020 - Wiley Online Library
Neurodegenerative disease is an umbrella term for different conditions which primarily affect
the neurons in the human brain. In the last century, significant research has been focused on …