For decades tumors have been recognized as “wounds that do not heal.” Besides the
commonalities that tumors and wounded tissues share, the process of wound healing also …

Many lung diseases result in fibrotic remodelling. Fibrotic lung disorders can be divided into
diseases with known and unknown aetiology. Among those with unknown aetiology …

Following tissue injury, a complex and coordinated wound healing response comprising
coagulation, inflammation, fibroproliferation and tissue remodelling has evolved to nullify the …

Fibroblast activation protein (FAP) belongs to the dipeptidyl peptidase IV (DPP4; CD26)
gene family. Other related genes in this family of enzyme include DPP4, 8 and 9. The FAP …

Fibrinogen plays an important role in blood coagulation but its function extends far beyond
blood clotting being involved in inflammation and repair. Besides these crucial functions it …

The urokinase-type plasminogen activator (uPA), its receptor (uPAR), and plasminogen
activator inhibitor-1 (PAI-1) are key components of the fibrinolytic system and are expressed …

Fibrinogen (Fg) has been implicated in the pathogenesis of several fibrotic disorders by
acting as a profibrotic ligand for a variety of cellular surface receptors and by modulating the …

Abstract Protease-activated receptor (PAR)-1 has emerged as a key profibrotic player in
various organs including kidney. PAR-1 activation leads to deposition of extracellular matrix …

Protease-activated receptor 4 (PAR4) is a G protein-coupled receptor activated by thrombin.
In the platelet, response to thrombin PAR4 contributes to the predominant procoagulant …

Objective—Macrophage (Mφ) migration rests on the adhesion/detachment between Mφ
surface components and extracellular matrixes, and the contribution of numerous …