Over the past 25 years, research in cancer therapeutics has largely focused on two distinct
lines of enquiry. In one approach, efforts to understand the underlying cell-autonomous …

Tumor necrosis factor receptor (TNFR)‐associated factor 6 (TRAF 6) is an adapter protein
that mediates a wide array of protein–protein interactions via its TRAF domain and a RING …

The nuclear factor-κB (NF-κB)/REL family of transcription factors has a central role in
coordinating the expression of a wide variety of genes that control immune responses. There …

Nuclear factor-κB (NF-κB) transcription factors and the signalling pathways that activate
them are central coordinators of innate and adaptive immune responses. More recently, it …

The transcription factor NF-κB has been the focus of intense investigation for nearly two
decades. Over this period, considerable progress has been made in determining the …

The regulation of the transcription factor NF-κB activity occurs at several levels including
controlled cytoplasmic-nuclear shuttling and modulation of its transcriptional activity. A …

Nuclear factor of κB (NF-κB) is a sequence-specific transcription factor that is known to be
involved in the inflammatory and innate immune responses. Although the importance of NF …

T‐cell activation is mediated by antigen‐specific signals from the TCRζ/CD3 and CD4–CD8–
p56lck complexes in combination with additional co‐signals provided by coreceptors such …

One of the primary physiological roles of nuclear factor-kappa B (NF-κB) is in the immune
system. In particular, NF-κB family members control the transcription of cytokines and …

Bone marrow-derived B cells make an important cell fate choice to develop into either
follicular B cells or marginal zone B cells in the spleen, which depends on signalling through …