Transcriptomics technologies

R Lowe, N Shirley, M Bleackley, S Dolan… - PLoS computational …, 2017 - journals.plos.org
Transcriptomics technologies are the techniques used to study an organism's transcriptome,
the sum of all of its RNA transcripts. The information content of an organism is recorded in …

Helping koalas battle disease – Recent advances in Chlamydia and koala retrovirus (KoRV) disease understanding and treatment in koalas

BL Quigley, P Timms - FEMS Microbiology Reviews, 2020 - academic.oup.com
The iconic Australian marsupial, the koala (Phascolarctos cinereus), has suffered dramatic
population declines as a result of habitat loss and fragmentation, disease, vehicle collision …

Adaptation and conservation insights from the koala genome

RN Johnson, D O'Meally, Z Chen, GJ Etherington… - Nature …, 2018 - nature.com
The koala, the only extant species of the marsupial family Phascolarctidae, is classified as
'vulnerable'due to habitat loss and widespread disease. We sequenced the koala genome …

The piRNA response to retroviral invasion of the koala genome

T Yu, BS Koppetsch, S Pagliarani, S Johnston… - Cell, 2019 - cell.com
Summary Antisense Piwi-interacting RNAs (piRNAs) guide silencing of established
transposons during germline development, and sense piRNAs drive ping-pong amplification …

Analysis of phylogenomic tree space resolves relationships among marsupial families

DA Duchêne, JG Bragg, S Duchêne… - Systematic …, 2018 - academic.oup.com
A fundamental challenge in resolving evolutionary relationships across the tree of life is to
account for heterogeneity in the evolutionary signal across loci. Studies of marsupial …

Transspecies transmission of gammaretroviruses and the origin of the gibbon ape leukaemia virus (GaLV) and the koala retrovirus (KoRV)

J Denner - Viruses, 2016 - mdpi.com
Transspecies transmission of retroviruses is a frequent event, and the human
immunodeficiency virus-1 (HIV-1) is a well-known example. The gibbon ape leukaemia virus …

Rethinking the starch digestion hypothesis for AMY1 copy number variation in humans

CI Fernández, AS Wiley - American journal of physical …, 2017 - Wiley Online Library
Alpha‐amylase exists across taxonomic kingdoms with a deep evolutionary history of gene
duplications that resulted in several α‐amylase paralogs. Copy number variation (CNV) in …

Retroviral integrations contribute to elevated host cancer rates during germline invasion

GK McEwen, DE Alquezar-Planas, A Dayaram… - Nature …, 2021 - nature.com
Repeated retroviral infections of vertebrate germlines have made endogenous retroviruses
ubiquitous features of mammalian genomes. However, millions of years of evolution obscure …

Koala retrovirus genetic diversity and transmission dynamics within captive koala populations

BA Joyce, MDJ Blyton, SD Johnston… - Proceedings of the …, 2021 - National Acad Sciences
Koala populations are currently in rapid decline across Australia, with infectious diseases
being a contributing cause. The koala retrovirus (KoRV) is a gammaretrovirus present in …

Degradation and remobilization of endogenous retroviruses by recombination during the earliest stages of a germ-line invasion

U Löber, M Hobbs, A Dayaram… - Proceedings of the …, 2018 - National Acad Sciences
Endogenous retroviruses (ERVs) are proviral sequences that result from colonization of the
host germ line by exogenous retroviruses. The majority of ERVs represent defective …