Coronavirus disease (COVID-19) presents a broad spectrum of clinical manifestations
ranging from an asymptomatic to a severe clinical course. The host genetic background …

Respiratory disorders, especially non-communicable, chronic inflammatory diseases, are
amongst the leading causes of mortality and morbidity worldwide. Respiratory diseases …

2018 marks the 100-year anniversary of the 1918 influenza pandemic, which killed~ 50
million people worldwide. The severity of this pandemic resulted from a complex interplay …

Antiviral activities of antibodies may either be dependent only on interactions between the
antibody and cognate antigen, as in binding and neutralization of an infectious virion, or …

The world had been anticipating another influenza pandemic since the last one in 1968. The
pandemic influenza A H1N1 2009 virus (A/2009/H1N1) finally arrived, causing the first …

Influenza viruses continue to be a major global health threat. Severity and clinical outcome
of influenza disease is determined by both viral and host factors. Viral factors have long …

Influenza A viruses (IAVs) remain a major health threat and a prime example of the
significance of innate immunity. Our understanding of innate immunity to IAV has grown …

Background The World Health Organization has identified studies of the role of host genetics
on susceptibility to severe influenza as a priority. A systematic review was conducted to …

Pneumonia is a complex pulmonary disease in need of new clinical approaches. Although
triggered by a pathogen, pneumonia often results from dysregulations of host defense that …

There is abundant evidence that the innate immune response to influenza A virus (IAV) is
highly complex and plays a key role in protection against IAV induced infection and illness …