Mechanical signalling affects multiple biological processes during development and in adult organisms, including cell fate transitions, cell migration, morphogenesis and immune …
Biomolecular and physical cues of the extracellular matrix environment regulate collective cell dynamics and tissue patterning. Nonetheless, how the viscoelastic properties of the …
Genomes have complex three-dimensional architectures. The recent convergence of genetic, biochemical, biophysical, and cell biological methods has uncovered several …
INTRODUCTION Human beings are equipped with multiple senses (sight, hearing, smell, taste, touch, and proprioception) to help them to react properly to their environment. The …
C Collinet, T Lecuit - Nature Reviews Molecular Cell Biology, 2021 - nature.com
How the shape of embryos and organs emerges during development is a fundamental question that has fascinated scientists for centuries. Tissue dynamics arise from a small set …
In recent years considerable progress has been made in the development of faithful procedures for the differentiation of human pluripotent stem cells (hPSCs). An important step …
Final organ size and shape result from volume expansion by growth and shape changes by contractility. Complex morphologies can also arise from differences in growth rate between …
X Liu, Y Ye, L Zhu, X Xiao, B Zhou, Y Gu, H Si… - Nature …, 2023 - nature.com
Emerging evidence shows that the biomechanical environment is required to support cancer stem cells (CSCs), which play a crucial role in drug resistance. However, how …
C Ligorio, A Mata - Nature reviews bioengineering, 2023 - nature.com
The communication of cells with their surroundings is mostly encoded in the epitopes of structural and signalling proteins present in the extracellular matrix (ECM). These peptide …