As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …

Mechanical signalling affects multiple biological processes during development and in adult
organisms, including cell fate transitions, cell migration, morphogenesis and immune …

Biomolecular and physical cues of the extracellular matrix environment regulate collective
cell dynamics and tissue patterning. Nonetheless, how the viscoelastic properties of the …

Genomes have complex three-dimensional architectures. The recent convergence of
genetic, biochemical, biophysical, and cell biological methods has uncovered several …

INTRODUCTION Human beings are equipped with multiple senses (sight, hearing, smell,
taste, touch, and proprioception) to help them to react properly to their environment. The …

How the shape of embryos and organs emerges during development is a fundamental
question that has fascinated scientists for centuries. Tissue dynamics arise from a small set …

In recent years considerable progress has been made in the development of faithful
procedures for the differentiation of human pluripotent stem cells (hPSCs). An important step …

Final organ size and shape result from volume expansion by growth and shape changes by
contractility. Complex morphologies can also arise from differences in growth rate between …

Emerging evidence shows that the biomechanical environment is required to support cancer
stem cells (CSCs), which play a crucial role in drug resistance. However, how …

The communication of cells with their surroundings is mostly encoded in the epitopes of
structural and signalling proteins present in the extracellular matrix (ECM). These peptide …