Lensless imaging and sensing

A Ozcan, E McLeod - Annual review of biomedical engineering, 2016 - annualreviews.org
High-resolution optical microscopy has traditionally relied on high-magnification and high–
numerical aperture objective lenses. In contrast, lensless microscopy can provide high …

Lensless digital holographic microscopy and its applications in biomedicine and environmental monitoring

Y Wu, A Ozcan - Methods, 2018 - Elsevier
Optical compound microscope has been a major tool in biomedical imaging for centuries. Its
performance relies on relatively complicated, bulky and expensive lenses and alignment …

Optical imaging techniques for point-of-care diagnostics

H Zhu, SO Isikman, O Mudanyali, A Greenbaum… - Lab on a Chip, 2013 - pubs.rsc.org
Improving access to effective and affordable healthcare has long been a global endeavor. In
this quest, the development of cost-effective and easy-to-use medical testing equipment that …

Edge sparsity criterion for robust holographic autofocusing

Y Zhang, H Wang, Y Wu, M Tamamitsu, A Ozcan - Optics letters, 2017 - opg.optica.org
Autofocusing is essential to digital holographic imaging. Previously used autofocusing
criteria exhibit challenges when applied to, eg, connected objects with different optical …

Cost-effective and compact wide-field fluorescent imaging on a cell-phone

H Zhu, O Yaglidere, TW Su, D Tseng, A Ozcan - Lab on a Chip, 2011 - pubs.rsc.org
We demonstrate wide-field fluorescent and darkfield imaging on a cell-phone with compact,
light-weight and cost-effective optical components that are mechanically attached to the …

Deep learning-based cell identification and disease diagnosis using spatio-temporal cellular dynamics in compact digital holographic microscopy

T O'Connor, A Anand, B Andemariam… - Biomedical Optics …, 2020 - opg.optica.org
We demonstrate a successful deep learning strategy for cell identification and disease
diagnosis using spatio-temporal cell information recorded by a digital holographic …

Review of quantitative phase-digital holographic microscopy: promising novel imaging technique to resolve neuronal network activity and identify cellular biomarkers …

P Marquet, C Depeursinge, PJ Magistretti - Neurophotonics, 2014 - spiedigitallibrary.org
Quantitative phase microscopy (QPM) has recently emerged as a new powerful quantitative
imaging technique well suited to noninvasively explore a transparent specimen with a …

Lens-free optical tomographic microscope with a large imaging volume on a chip

SO Isikman, W Bishara, S Mavandadi… - Proceedings of the …, 2011 - National Acad Sciences
We present a lens-free optical tomographic microscope, which enables imaging a large
volume of approximately 15 mm3 on a chip, with a spatial resolution of< 1 μm×< 1 μm×< 3 …

Quantitative phase imaging based on holography: trends and new perspectives

Z Huang, L Cao - Light: Science & Applications, 2024 - nature.com
Abstract In 1948, Dennis Gabor proposed the concept of holography, providing a pioneering
solution to a quantitative description of the optical wavefront. After 75 years of development …

Unconventional methods of imaging: computational microscopy and compact implementations

E McLeod, A Ozcan - Reports on Progress in Physics, 2016 - iopscience.iop.org
In the past two decades or so, there has been a renaissance of optical microscopy research
and development. Much work has been done in an effort to improve the resolution and …