Communicating clocks shape circadian homeostasis
KB Koronowski, P Sassone-Corsi - Science, 2021 - science.org
BACKGROUND Life-forms ranging from bacteria to humans are programmed by circadian
clocks—mechanisms that impose an~ 24-hour rhythmicity on biology in harmony with …
clocks—mechanisms that impose an~ 24-hour rhythmicity on biology in harmony with …
Interconnections between circadian clocks and metabolism
Circadian rhythms evolved through adaptation to daily light/dark changes in the
environment; they are believed to be regulated by the core circadian clock interlocking …
environment; they are believed to be regulated by the core circadian clock interlocking …
Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms
The circadian clock and feeding rhythms are both important regulators of rhythmic gene
expression in the liver. To further dissect the respective contributions of feeding and the …
expression in the liver. To further dissect the respective contributions of feeding and the …
Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms
The mammalian circadian clock, expressed throughout the brain and body, controls daily
metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for …
metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for …
The liver-clock coordinates rhythmicity of peripheral tissues in response to feeding
G Manella, E Sabath, R Aviram, V Dandavate… - Nature …, 2021 - nature.com
The mammalian circadian system consists of a central clock in the brain that synchronizes
clocks in the peripheral tissues. Although the hierarchy between central and peripheral …
clocks in the peripheral tissues. Although the hierarchy between central and peripheral …
The role and mechanism of oxidative stress and nuclear receptors in the development of NAFLD
T Hong, Y Chen, X Li, Y Lu - Oxidative medicine and cellular …, 2021 - Wiley Online Library
The overproduction of reactive oxygen species (ROS) and consequent oxidative stress
contribute to the pathogenesis of acute and chronic liver diseases. It is now acknowledged …
contribute to the pathogenesis of acute and chronic liver diseases. It is now acknowledged …
Circadian clocks in the digestive system
A Segers, I Depoortere - Nature Reviews Gastroenterology & …, 2021 - nature.com
Many molecular, physiological and behavioural processes display distinct 24-hour rhythms
that are directed by the circadian system. The master clock, located in the suprachiasmatic …
that are directed by the circadian system. The master clock, located in the suprachiasmatic …
Daytime eating prevents internal circadian misalignment and glucose intolerance in night work
Night work increases diabetes risk. Misalignment between the central circadian “clock” and
daily behaviors, typical in night workers, impairs glucose tolerance, likely due to internal …
daily behaviors, typical in night workers, impairs glucose tolerance, likely due to internal …
Hepatocytes demarcated by EphB2 contribute to the progression of nonalcoholic steatohepatitis
Current therapeutic strategies for treating nonalcoholic steatohepatitis (NASH) have failed to
alleviate liver fibrosis, which is a devastating feature leading to hepatic dysfunction. Here …
alleviate liver fibrosis, which is a devastating feature leading to hepatic dysfunction. Here …
Circadian hepatocyte clocks keep synchrony in the absence of a master pacemaker in the suprachiasmatic nucleus or other extrahepatic clocks
It has been assumed that the suprachiasmatic nucleus (SCN) synchronizes peripheral
circadian oscillators. However, this has never been convincingly shown, since biochemical …
circadian oscillators. However, this has never been convincingly shown, since biochemical …