Phaeodactylum tricornutum: a diatom cell factory

T Butler, RV Kapoore, S Vaidyanathan - Trends in biotechnology, 2020 - cell.com
A switch from a petroleum-based to a biobased economy requires the capacity to produce
both high-value low-volume and low-value high-volume products. Recent evidence supports …

Genome-scale metabolic modeling enables in-depth understanding of big data

A Passi, JD Tibocha-Bonilla, M Kumar, D Tec-Campos… - Metabolites, 2021 - mdpi.com
Genome-scale metabolic models (GEMs) enable the mathematical simulation of the
metabolism of archaea, bacteria, and eukaryotic organisms. GEMs quantitatively define a …

RAVEN 2.0: A versatile toolbox for metabolic network reconstruction and a case study on Streptomyces coelicolor

H Wang, S Marcišauskas, BJ Sánchez… - PLoS computational …, 2018 - journals.plos.org
RAVEN is a commonly used MATLAB toolbox for genome-scale metabolic model (GEM)
reconstruction, curation and constraint-based modelling and simulation. Here we present …

BiGG Models 2020: multi-strain genome-scale models and expansion across the phylogenetic tree

CJ Norsigian, N Pusarla, JL McConn… - Nucleic acids …, 2020 - academic.oup.com
Abstract The BiGG Models knowledge base (http://bigg. ucsd. edu) is a centralized
repository for high-quality genome-scale metabolic models. For the past 12 years, the …

Mixotrophic cultivation of microalgae: an alternative to produce high-value metabolites

T Castillo, D Ramos, T García-Beltrán… - Biochemical …, 2021 - Elsevier
Microalgae are important sources of biotechnological products, including pigments, lipids,
polyunsaturated fatty acids, polysaccharides, vitamins, and other bioactive compounds …

Evolution and regulation of nitrogen flux through compartmentalized metabolic networks in a marine diatom

SR Smith, CL Dupont, JK McCarthy… - Nature …, 2019 - nature.com
Diatoms outcompete other phytoplankton for nitrate, yet little is known about the
mechanisms underpinning this ability. Genomes and genome-enabled studies have shown …

Diatoms biotechnology: various industrial applications for a greener tomorrow

N Sharma, DP Simon, AM Diaz-Garza… - Frontiers in Marine …, 2021 - frontiersin.org
The benefits of the complex microscopic and industrially important group of microalgae such
as diatoms is not hidden and have lately surprised the scientific community with their …

Diatom molecular research comes of age: model species for studying phytoplankton biology and diversity

A Falciatore, M Jaubert, JP Bouly, B Bailleul… - The Plant …, 2020 - academic.oup.com
Diatoms are the world's most diverse group of algae, comprising at least 100,000 species.
Contributing~ 20% of annual global carbon fixation, they underpin major aquatic food webs …

A critical review of genome editing and synthetic biology applications in metabolic engineering of microalgae and cyanobacteria

IS Ng, BB Keskin, SI Tan - Biotechnology Journal, 2020 - Wiley Online Library
Being the green gold of the future, microalgae and cyanobacteria have recently attracted
considerable interest worldwide, for their metabolites such as lipids, protein, pigments, and …

Elucidation of complexity and prediction of interactions in microbial communities

C Zuñiga, L Zaramela, K Zengler - Microbial biotechnology, 2017 - Wiley Online Library
Microorganisms engage in complex interactions with other members of the microbial
community, higher organisms as well as their environment. However, determining the exact …