Main drivers of (poly) phenol effects on human health: metabolite production and/or gut microbiota-associated metabotypes?

CE Iglesias-Aguirre, A Cortés-Martín… - Food & function, 2021 - pubs.rsc.org
Despite the high human interindividual variability in response to (poly) phenol consumption,
the cause-and-effect relationship between some dietary (poly) phenols (flavanols and olive …

Microbial phenolic metabolites: which molecules actually have an effect on human health?

M Marhuenda-Muñoz, EP Laveriano-Santos… - Nutrients, 2019 - mdpi.com
The role of gut microbiota in human health has been investigated extensively in recent
years. The association of dysbiosis, detrimental changes in the colonic population, with …

UHPLC-HRMS spectrometric analysis: Method validation and plasma and urinary metabolite identification after mango pulp intake

S Cáceres-Jiménez, R Rodríguez-Solana… - Journal of Agricultural …, 2023 - ACS Publications
After an acute intake of 300 g of mango purée by 10 subjects, 0 and 24 h urine and plasma
samples were analyzed by high-performance liquid chromatography–high-resolution mass …

Blood pressure and body fat% reduction is mainly related to flavanone phase II conjugates and minor extension by phenolic acid after long-term intake of orange juice

LN Fraga, CP Coutinho, AC Rozenbaum… - Food & function, 2021 - pubs.rsc.org
Hesperidin and narirutin are the major flavanones present in orange juice, and they are
associated with a reduction in risk of cardiometabolic disease. However, there is …

Metabolomics technologies for the identification and quantification of dietary phenolic compound metabolites: an overview

A López-Yerena, I Domínguez-López… - Antioxidants, 2021 - mdpi.com
In the search for natural products with properties that may protect against or slow down
chronic and degenerative diseases (eg, cancer, and cardiovascular and neurodegenerative …

Recent analytical approaches for the study of bioavailability and metabolism of bioactive phenolic compounds

Á Fernández-Ochoa, ML Cádiz-Gurrea… - Molecules, 2022 - mdpi.com
The study of the bioavailability of bioactive compounds is a fundamental step for the
development of applications based on them, such as nutraceuticals, functional foods or …

Quantitative assessment of dietary (poly) phenol intake: A high-throughput targeted metabolomics method for blood and urine samples

M Domínguez-Fernández, Y Xu… - Journal of agricultural …, 2020 - ACS Publications
Many studies have associated the consumption of (poly) phenol-rich diets with health
benefits. However, accurate high-throughput quantitative methods for estimating exposure …

Metabolism of phenolics in coffee and plant-based foods by canonical pathways: an assessment of the role of fatty acid β-oxidation to generate biologically-active and …

MN Clifford, LJ King, A Kerimi… - Critical reviews in …, 2024 - Taylor & Francis
Abstract ω-Phenyl-alkenoic acids are abundant in coffee, fruits, and vegetables. Along with
ω-phenyl-alkanoic acids, they are produced from numerous dietary (poly) phenols and …

4-Hydroxydibenzyl: A novel metabolite from the human gut microbiota after consuming resveratrol

CE Iglesias-Aguirre, F Vallejo, D Beltrán, J Berná… - Food & function, 2022 - pubs.rsc.org
Resveratrol (RSV) was known to be metabolised by the gut microbiota to dihydroresveratrol,
lunularin (LUNU), and (or) 3, 4′-dihydroxy-trans-stilbene (DHST). We describe here for the …

Effect of rootstock and harvesting period on the bioactive compounds and antioxidant activity of two orange cultivars ('Salustiana'and 'Sanguinelli') widely used in juice …

JL Ordóñez-Díaz, A Hervalejo, G Pereira-Caro… - Processes, 2020 - mdpi.com
Oranges are a rich source of bioactive compounds with recognized benefits for human
health. To guarantee high quality and production levels, citrus farms usually employ the …