Minimizing second cancer risk following radiotherapy: current perspectives

J Ng, I Shuryak - Cancer management and research, 2014 - Taylor & Francis
Secondary cancer risk following radiotherapy is an increasingly important topic in clinical
oncology with impact on treatment decision making and on patient management. Much of …

AAPM TG 158: measurement and calculation of doses outside the treated volume from external‐beam radiation therapy

SF Kry, B Bednarz, RM Howell, L Dauer… - Medical …, 2017 - Wiley Online Library
The introduction of advanced techniques and technology in radiotherapy has greatly
improved our ability to deliver highly conformal tumor doses while minimizing the dose to …

Modeling the risk of secondary malignancies after radiotherapy

U Schneider - Genes, 2011 - mdpi.com
In developed countries, more than half of all cancer patients receive radiotherapy at some
stage in the management of their disease. However, a radiation-induced secondary …

Site-specific dose-response relationships for cancer induction from the combined Japanese A-bomb and Hodgkin cohorts for doses relevant to radiotherapy

U Schneider, M Sumila, J Robotka - Theoretical Biology and Medical …, 2011 - Springer
Abstract Background and Purpose Most information on the dose-response of radiation-
induced cancer is derived from data on the A-bomb survivors. Since, for radiation protection …

Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B

MY Deng, D Sturm, E Pfaff, M Sill, D Stichel… - Nature …, 2021 - nature.com
Long-term complications such as radiation-induced second malignancies occur in a subset
of patients following radiation-therapy, particularly relevant in pediatric patients due to the …

Radiobiological risk estimates of adverse events and secondary cancer for proton and photon radiation therapy of pediatric medulloblastoma

NP Brodin, PMAF Rosenschöld, MC Aznar… - Acta …, 2011 - Taylor & Francis
Introduction. The aim of this model study was to estimate and compare the risk of radiation-
induced adverse late effects in pediatric patients with medulloblastoma (MB) treated with …

A planning comparison of dose patterns in organs at risk and predicted risk for radiation induced malignancy in the contralateral breast following radiation therapy of …

S Johansen, L Cozzi, DR Olsen - Acta Oncologica, 2009 - Taylor & Francis
Purpose. To investigate the impact of using different radiation therapy techniques on contra-
lateral breast (CB) dose, and also dose to other involved organs at risk such as heart and …

Mechanistic model of radiation‐induced cancer after fractionated radiotherapy using the linear‐quadratic formula

U Schneider - Medical physics, 2009 - Wiley Online Library
A simple mechanistic model for predicting cancer induction after fractionated radiotherapy is
developed. The model is based upon the linear‐quadratic model. The inductions of …

Evaluation of organ-specific peripheral doses after 2-dimensional, 3-dimensional and hybrid intensity modulated radiation therapy for breast cancer based on Monte …

A Joosten, O Matzinger, W Jeanneret-Sozzi… - Radiotherapy and …, 2013 - Elsevier
BACKGROUND AND PURPOSE: To make a comprehensive evaluation of organ-specific
out-of-field doses using Monte Carlo (MC) simulations for different breast cancer irradiation …

A new view of radiation-induced cancer: integrating short-and long-term processes. Part II: second cancer risk estimation

I Shuryak, P Hahnfeldt, L Hlatky, RK Sachs… - Radiation and …, 2009 - Springer
As the number of cancer survivors grows, prediction of radiotherapy-induced second cancer
risks becomes increasingly important. Because the latency period for solid tumors is long …