Aging is a complex biological process characterized by hallmark features accumulating over
the life course, shaping the individual's aging trajectory and subsequent disease risks. There …

Cellular metabolism and environmental interactions generate molecular damage affecting
all levels of biological organization. Accumulation of this damage over time is thought to …

Aging is emerging as a druggable target with growing interest from academia, industry and
investors. New technologies such as artificial intelligence and advanced screening …

Extreme longevity in humans has a strong genetic component, but whether this involves
genetic variation in the same longevity pathways as found in model organisms is unclear …

Cells may naturally proceed or be forced to transition to a state with a radically lower
biological age, that is, be rejuvenated. Examples are the conversion of somatic cells to …

The protein alpha-synuclein (α-syn) is unusual because, depending on its conformation and
the type of cell in which it is expressed, it is pro-death or pro-survival, triggering …

We reconstruct the phenotype of Balto, the heroic sled dog renowned for transporting
diphtheria antitoxin to Nome, Alaska, in 1925, using evolutionary constraint estimates from …

Ageing is the greatest risk factor for most common chronic human diseases, and it therefore
is a logical target for developing interventions to prevent, mitigate or reverse multiple age …

The evolution of aging requires mutations with late-life deleterious effects. Classic theories
assume these mutations either have neutral (mutation accumulation) or beneficial …

Genetic predisposition has been shown to contribute substantially to the age at which we
die. Genome-wide association studies (GWASs) have linked more than 20 loci to …