Psychedelics are serotonin 2A receptor agonists that can lead to profound changes in
perception, cognition and mood. In this review, we focus on the basic neurobiology …

Psychedelic drugs including psilocybin, N, N ʹ-dimethyltryptamine (DMT) and lysergic acid
diethylamide (LSD) are undergoing a renaissance as potentially useful drugs for various …

In addition to producing profound subjective effects following acute administration,
psychedelic compounds can induce beneficial behavioral changes relevant to the treatment …

Serotonin 5-HT2A receptors (5-HT2ARs) are widely distributed in the central nervous
system, especially in brain region essential for learning and cognition. In addition to …

Over the past decade, psychedelic compounds have emerged as potentially transformative
therapeutics for a variety of intractable neuropsychiatric conditions. However, historically …

The 4 mammalian arrestins serve as almost universal regulators of the largest known family
of signaling proteins, G-protein-coupled receptors (GPCRs). Arrestins terminate receptor …

G-protein-coupled receptors (GPCRs) constitute a large and diverse family of proteins
whose primary function is to transduce extracellular stimuli into intracellular signals. They …

Recently, psychedelics have emerged as promising therapeutics for numerous
neuropsychiatric disorders. While their potential in the clinic has yet to be fully elucidated …

Visual and auditory hallucinations accompany certain neuropsychiatric disorders, such as
schizophrenia, and they also can be induced by the use or abuse of certain drugs. The …

A confluence of factors has renewed interest in the scientific understanding and translational
potential of psychedelic drugs such as lysergic acid diethylamide (LSD), mescaline, and …