Bone-tissue defects affect millions of people worldwide. Despite being common treatment
approaches, autologous and allogeneic bone grafting have not achieved the ideal …

Background Bone regeneration involves various complex biological processes. Many
experiments have been performed using biomaterials in vivo and in vitro to promote and …

Bone biomaterials play a vital role in bone repair by providing the necessary substrate for
cell adhesion, proliferation, and differentiation and by modulating cell activity and function. In …

The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

Due to a prolonged life expectancy, the number of orthopedic-related fractures and
pathologies is increasing, leading to a tremendous demand for efficient orthopedic …

Various strategies have been explored to overcome critically sized bone defects via bone
tissue engineering approaches that incorporate biomimetic scaffolds. Biomimetic scaffolds …

The stem cell/material interface is a complex, dynamic microenvironment in which the cell
and the material cooperatively dictate one another's fate: the cell by remodelling its …

The discovery of osteoinductivity of calcium phosphate (Ca-P) ceramics has set an enduring
paradigm of conferring biological regenerative activity to materials with carefully designed …

The qualities of polymer based biomaterials in facilitating bone regeneration process
through tissue engineering have attracted the attention of researchers. Biomaterials with …

Clay nanoparticles, composites and hydrogels are emerging as a new class of biomaterial
with exciting potential for tissue engineering and regenerative medicine applications. Clay …