Pigs have substantial potential as biomedical models for studying human developmental
processes, congenital diseases, and pathogen response mechanisms in addition to utility as …

The mammalian retina displays no intrinsic regenerative capacities, therefore retinal
degenerative diseases such as age-related macular degeneration (AMD) or retinitis …

One of the most powerful strategies to investigate biology we have as scientists, is the ability
to transfer genetic material in a controlled and deliberate manner between organisms. When …

Hereditary cone disorders (CDs) are characterized by defects of the cone photoreceptors or
retinal pigment epithelium underlying the macula, and include achromatopsia (ACHM), cone …

Over the last decade, huge progress has been made in the understanding of the molecular
mechanisms underlying inherited retinal dystrophy (IRD), as well as in the development and …

Although rare in the general population, retinal dystrophies occupy a central position in
current efforts to develop innovative therapies for blinding diseases. This status derives, in …

The GUCY2D gene encodes for the photoreceptor guanylate cyclase GC-E that synthesizes
the intracellular messenger of photoreceptor excitation cGMP and is regulated by …

The first transgenic pigs were generated for agricultural purposes about three decades ago.
Since then, the micromanipulation techniques of pig oocytes and embryos expanded from …

Disease‐causing variants of a large number of genes trigger inherited retinal degeneration
leading to photoreceptor loss. Because cones are essential for daylight and central vision …

Pigs have anatomical, physiological and genomic characteristics that make them highly
suitable for modeling human diseases. Genetically modified (GM) pig models of human …