Cross-species comparisons of genomes, transcriptomes and gene regulation are now
feasible at unprecedented resolution and throughput, enabling the comparison of human …

Non-alcoholic fatty liver disease (NAFLD) is associated with a thorough reprogramming of
hepatic metabolism. Epigenetic mechanisms, in particular those associated with …

Post-transcriptional gene regulation (PTGR) of mRNA turnover, localization and translation
is mediated by microRNAs (miRNAs) and RNA-binding proteins (RBPs). These regulators …

MicroRNAs (miRNAs) are major post-transcriptional regulators of gene expression, yet their
origins and functional evolution in mammals remain little understood due to the lack of …

Gene expression changes may underlie much of phenotypic evolution. The development of
high-throughput RNA sequencing protocols has opened the door to unprecedented large …

Germline mutations that activate genes in the canonical RAS/MAPK signaling pathway are
responsible for rare human developmental disorders known as RASopathies. Here, we …

Stem cell-based therapeutic approaches for neurological disorders are widely studied.
Paracrine factors secreted by stem cells in vitro and delivered intranasally might allow …

Non-alcoholic fatty liver disease (NAFLD) is now the most common cause of chronic liver
disease, worldwide. The molecular pathogenesis of NAFLD is complex, involving numerous …

MicroRNAs (miRNAs) are endogenous, small non-coding RNA molecules that mediate post-
transcriptional gene suppression by incomplete matches with their host mRNAs. In the …

The use of easily accessible peripheral samples, such as blood or saliva, to investigate
neurological and neuropsychiatric disorders is well-established in genetic and epigenetic …