The role of calcium ions (Ca2+) in cell functions is beginning to be unraveled at the
molecular level as a result of recent research on calcium-binding proteins and particularly …

Calmodulin, a protein that binds calcium with high affinity and specificity, is structurally
conserved and functionally preserved throughout the animal and plant kingdoms. It serves …

Nile red is an uncharged hydrophobic molecule whose fluorescence is strongly influenced
by the polarity of its environment. It interacts with many, but not all, native proteins, including …

The inhibitory protein that binds calmodulin and thus prevents activation of several Ca2+-
dependent enzymes by calmodulin is shown to also bind four Ca2+ per mol of protein with …

The three-dimensional structure of calmodulin has been determined crystallographically at
3.0 Å resolution. The molecule consists of two globular lobes connected by a long exposed …

The macroscopic Ca (2+)-binding constants of bovine calmodulin have been determined
from titrations with Ca2+ in the presence of the chromophoric chelator 5, 5'-Br2BAPTA in 0 …

We have isolated a number of Drosophila cDNAs on the basis of their encoding calmodulin-
binding proteins. A full-length cDNA clone corresponding to one of these genes has been …

Publisher Summary Calmodulin is the major intracellular, and intramembrane, Ca 2+
receptor. Its function is to detect free Ca 2+ and translate changes in Ca 2+ concentrations …

The active form of calmodulin is a Ca2+. calmodulin complex. The purpose of this
investigation was to determine whether other metal cations substitute for Ca2+ to activate …

The functional implications of this model are discussed by Kretsinger. 1* 8 Here I wish to
focus on the structure and evolution of calcium-modulated proteins. I define a calcium …