[HTML][HTML] Thymoquinone: A novel strategy to combat cancer: A review

M Imran, A Rauf, IA Khan, M Shahbaz… - Biomedicine & …, 2018 - Elsevier
The higher consumption of fruit, herbs, spices, and vegetables is well known and practical
strategy to cure human cancers owing to their presence of bioactive compounds. Among …

Bax/Bcl-2 cascade is regulated by the EGFR pathway: therapeutic targeting of non-small cell lung cancer

M Alam, S Alam, A Shamsi, M Adnan… - Frontiers in …, 2022 - frontiersin.org
Non-small cell lung carcinoma (NSCLC) comprises 80%–85% of lung cancer cases. EGFR
is involved in several cancer developments, including NSCLC. The EGFR pathway …

Thymoquinone synergizes gemcitabine anti-breast cancer activity via modulating its apoptotic and autophagic activities

HA Bashmail, AA Alamoudi, A Noorwali, GA Hegazy… - Scientific reports, 2018 - nature.com
The use of anti-cancer adjuvant therapy is rationalized by potentiating the efficacy, and/or
protecting from major side effects of chemotherapeutics. Thymoquinone (TQ) is a naturally …

Thymoquinone inhibits the metastasis of renal cell cancer cells by inducing autophagy via AMPK/mTOR signaling pathway

Y Zhang, Y Fan, S Huang, G Wang, R Han… - Cancer …, 2018 - Wiley Online Library
Abstract Thymoquinone (TQ, 2‐methyl‐5‐isopropyl‐1, 4‐benzoquinone), a bioactive
constituent extracted from the seeds of Nigella sativa, has been proved to exert anti‐tumor …

Anticancer activity of thymoquinone cubic phase nanoparticles against human breast cancer: Formulation, cytotoxicity and subcellular localization

MM Mehanna, R Sarieddine, JK Alwattar… - International Journal …, 2020 - Taylor & Francis
Introduction Triple negative breast cancer is an aggressive disorder which accounts for at
least 15% of breast cancer diagnosis and a high percentage of breast cancer morbidity …

RETRACTED: Thymoquinone-Loaded Soy-Phospholipid-Based Phytosomes Exhibit Anticancer Potential against Human Lung Cancer Cells

NA Alhakamy, SM Badr-Eldin, UA Fahmy, NK Alruwaili… - Pharmaceutics, 2020 - mdpi.com
Thymoquinone (TQ), a natural polyphenol, has been associated with various
pharmacological responses; however, low bioavailability of TQ limits its clinical application …

Nutritional Value and Preventive Role of Nigella sativa L. and Its Main Component Thymoquinone in Cancer: An Evidenced-Based Review of Preclinical and Clinical …

J Ansary, F Giampieri, TY Forbes-Hernandez, L Regolo… - Molecules, 2021 - mdpi.com
In recent times, scientific attention has been paid to different foods and their bioactive
components for the ability to inhibit the onset and progress of different types of cancer …

Novel thymoquinone lipidic core nanocapsules with anisamide-polymethacrylate shell for colon cancer cells overexpressing sigma receptors

L Ramzy, AA Metwally, M Nasr, GAS Awad - Scientific reports, 2020 - nature.com
The biggest challenge in colorectal cancer therapy is to avoid intestinal drug absorption
before reaching the colon, while focusing on tumor specific delivery with high local …

Therapeutic perspectives of the black cumin component thymoquinone: A review

C Sarkar, S Jamaddar, T Islam, M Mondal, MT Islam… - Food & Function, 2021 - pubs.rsc.org
The dietary phytochemical thymoquinone (TQ), belonging to the family of quinones, mainly
obtained from the black and angular seeds of Nigella sativa, is one of the promising …

Modulation of diverse oncogenic transcription factors by thymoquinone, an essential oil compound isolated from the seeds of Nigella sativa Linn

MK Shanmugam, F Arfuso, AP Kumar, L Wang… - Pharmacological …, 2018 - Elsevier
Thymoquinone (TQ), isolated almost fifty years ago, is the main bioactive constituent of black
seed essential oil extracted from the seed of Nigella sativa. TQ has been shown to have …