[HTML][HTML] Anticancer activity of oleanolic acid and its derivatives: Recent advances in evidence, target profiling and mechanisms of action

ZY Tang, Y Li, YT Tang, XD Ma, ZY Tang - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Abstract Oleanolic acid (OA, 3 β-hydroxyoleanolic acid-12-en-28-oic acid) is a pentacyclic
triterpenoid present in many plants. As a new framework for development of semi synthetic …

Epigenetics/epigenomics of triterpenoids in cancer prevention and in health

S Li, HCD Kuo, R Yin, R Wu, X Liu, L Wang… - Biochemical …, 2020 - Elsevier
Triterpenoids are a powerful group of phytochemicals derived from plant foods and herbs.
Many reports have shown that they possess chemopreventive and chemotherapeutic effects …

An oleanolic acid derivative, K73‐03, inhibits pancreatic cancer cells proliferation in vitro and in vivo via blocking EGFR/Akt pathway

Z Zhou, Y Dong, N Li, M Niu, S Wang… - Cell Biology …, 2022 - Wiley Online Library
Oleanolic acid (OA) and its derivatives show potent anticancer function. Pancreatic cancer
(PC) is the fourth core motive of cancer‐related deaths worldwide. Epidermal growth factor …

Inhibitory effect of emodin on migration, invasion and metastasis of human breast cancer MDA-MB-231 cells in vitro and in vivo

Y Sun, X Wang, Q Zhou, Y Lu, H Zhang… - Oncology …, 2015 - spandidos-publications.com
In breast cancer, metastasis is the main reason for patient mortality. In the present study, we
used breast cancer MDA-MB-231 cells and a mouse xenograft model to demonstrate the …

LC-HR/MS Analysis of Lipophilic Extracts from Calendula arvensis (Vaill.) L. Organs: An Unexplored Source in Cosmeceuticals

C Gravina, M Fiorentino, M Formato, MT Pecoraro… - Molecules, 2022 - mdpi.com
As part of a project aimed at promoting the use of Calendula arvensis (Vaill.) L.(field
marigold, Asteraceae) phytocomplexes in cosmeceutical formulations, the chemical …

Do recent research studies validate the medicinal plants used in British Columbia, Canada for pet diseases and wild animals taken into temporary care?

C Lans - Journal of Ethnopharmacology, 2019 - Elsevier
Ethnopharmacological relevance There are insufficient safe and effective treatments for
chronic pain in pets. In cases such as osteoarthritis there is no commercially available cure …

Antiproliferative Activity of Buddleja saligna (Willd.) against Melanoma and In Vivo Modulation of Angiogenesis

D Twilley, VC Thipe, N Kishore, P Bloebaum… - Pharmaceuticals, 2022 - mdpi.com
Melanoma cells secrete pro-angiogenic factors, which stimulates growth, proliferation and
metastasis, and therefore are key therapeutic targets. Buddleja saligna (BS), and an isolated …

Modulation of tumour-related signaling pathways by natural pentacyclic triterpenoids and their semisynthetic derivatives

A V. Markov, M A. Zenkova… - Current Medicinal …, 2017 - benthamdirect.com
Pentacyclic triterpenoids are a large class of natural isoprenoids that are widely
biosynthesized in higher plants. These compounds are potent anticancer agents that exhibit …

Cytotoxic activity of the chemical constituents of Clerodendrum indicum and Clerodendrum villosum roots

P Somwong, R Suttisri - Journal of Integrative Medicine, 2018 - Elsevier
Objective The roots of two Thai medicinal plants, Clerodendrum indicum and Clerodendrum
villosum are found in traditional medicine practices. The aim of this research was to …

Natural compounds in the chemoprevention of malignant melanoma

C Danciu, C Soica, D Antal, E Alexa… - Anti-Cancer Agents …, 2018 - ingentaconnect.com
Malignant melanoma is a very aggressive form of skin cancer, with increasing rates every
year, with an etiology that derives from the transformation and uncontrolled growth of …