The bacterial cell-wall that forms a protective layer over the inner membrane is called the
murein sacculus–a tightly cross-linked peptidoglycan mesh unique to bacteria. Cell-wall …

Practical Handbook of Microbiology, 4th edition provides basic, clear and concise
knowledge and practical information about working with microorganisms. Useful to anyone …

Antibiotics and antibiotic resistance determinants, natural molecules closely related to
bacterial physiology and consistent with an ancient origin, are not only present in antibiotic …

The emergence of antibiotic resistance is a growing problem worldwide. Numerous studies
have demonstrated that heavy metals facilitate the spread of bacterial drug-resistance in the …

This study aimed to characterize the role of Pseudomonas aeruginosa low-molecular-mass
penicillin-binding proteins (LMM PBPs), namely, PBP4 (DacB), PBP5 (DacC), and PBP7 …

Insertion of new material into the Escherichia coli peptidoglycan (PG) sacculus between the
cytoplasmic membrane and the outer membrane requires a well-organized balance …

ABSTRACT A critical feature of a potential antimicrobial target is the characteristic of being
essential for growth and survival during host infection. For bacteria, genome-wide …

Gram-negative bacteria have effective methods of excluding toxic compounds, including a
largely impermeable outer membrane (OM) and a range of efflux pumps. Furthermore, when …

Vancomycin and β-lactams are clinically important antibiotics that inhibit the formation of
peptidoglycan cross-links, but their binding targets are different. The binding target of …

dd-Carboxypeptidases (dd-CPases) are low-molecular-mass (LMM) penicillin-binding
proteins (PBPs) that are mainly involved in peptidoglycan remodelling, but little is known …