Inflammation in the tumor microenvironment is a hallmark of cancer and is recognized as a
key characteristic of carcinogens. However, the failure of resolution of inflammation in …

Colorectal cancer (CRC) has one of the highest mortality rates despite the advancement of
treatment options. Aggressive CRC remains difficult to treat owing to the activation of …

The relationship between inflammation and cancer has been recognized since the 17th
century, 1 and we now know much about the cells, cytokines and physiological processes …

Colorectal cancer (CRC) ranks as the second among the causes of tumor death worldwide,
with an estimation of 1.9 million new cases in 2020 and more than 900,000 deaths. This rate …

Epithelial-to-mesenchymal transition (EMT) is defined as the transformation of an epithelial
cell into a spindle cell with the loss of membrane E-cadherin expression and the gain of …

The Notch cascade is a fundamental and highly conserved pathway able to control cell-fate.
The Notch pathway arises from the interaction of one of the Notch receptors (Notch1–4) with …

Patients with long-standing ulcerative colitis (UC) have an increased colorectal cancer
(CRC) risk. In this pilot study we evaluated the effect of Eicosapentaenoic acid as free fatty …

Fibrocellular membrane or epiretinal membrane (ERM) forms on the surface of the inner
limiting membrane (ILM) in the inner retina and alters the structure and function of the retina …

The invasive and lethal nature of Glioblastoma multiforme (GBM) necessitates the
continuous identification of molecular targets and search of efficacious therapies to inhibit …

Fatty acid (FA) metabolism, including the uptake, de novo synthesis and oxidation of FAs, is
critical for the survival, proliferation, differentiation and metastasis of cancer cells. Several …