Epilepsy, a neurological disease characterized by recurrent seizures, is often associated
with a history of previous lesions in the nervous system. Impaired regulation of the activation …

Introduction Ischemia–reperfusion injury (IRI) is the inexplicable aggravation of cellular
dysfunction that results in blood flow restoration to previously ischemic tissues. COX …

Background Microglia are innate immune cells of the brain that perform phagocytic and
inflammatory functions in disease conditions. Transcriptomic studies of acutely-isolated …

Background Brain inflammation contributes significantly to the pathophysiology of
Alzheimer's disease, and it is manifested by glial cell activation, increased production of …

Poor quality and quantity of sleep are very common in elderly people throughout the world.
Growing evidence has suggested that sleep disturbances could accelerate the process of …

Oligonucleotide therapies offer precision treatments for a variety of neurological diseases,
including epilepsy, but their deployment is hampered by the blood-brain barrier (BBB) …

Introduction: Neuroinflammation has a critical role in brain disorders. Cyclooxygenase
(COX) is one of the principal drug targets for the reduction of neuroinflammation; however …

Background Neuroinflammation is a key pathological component of neurodegenerative
disease and is characterized by microglial activation and the secretion of proinflammatory …

Astrocytes are highly activated following brain injuries, and their activation influences
neuronal survival. Additionally, SOX9 expression is known to increase in reactive astrocytes …

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system,
characterized by apoptotic death of mature oligodendrocytes, neuroinflammation, and motor …