Leptin, cardiovascular diseases and type 2 diabetes mellitus

N Katsiki, DP Mikhailidis, M Banach - Acta Pharmacologica Sinica, 2018 - nature.com
Leptin, an adipokine that is implicated in the control of food intake via appetite suppression,
may also stimulate oxidative stress, inflammation, thrombosis, arterial stiffness …

Leptin in anorexia and cachexia syndrome

DR Engineer, JM Garcia - International journal of peptides, 2012 - Wiley Online Library
Leptin is a product of the obese (OB) gene secreted by adipocytes in proportion to fat mass.
It decreases food intake and increases energy expenditure by affecting the balance between …

Extracellular overhydration linked with endothelial dysfunction in the context of inflammation in haemodialysis dependent chronic kidney disease

N Mitsides, T Cornelis, NJH Broers, NMP Diederen… - PLoS …, 2017 - journals.plos.org
Background Haemodialysis (HD) patients are predisposed to dysregulated fluid balance
leading to extracellular water (ECW) expansion. Fluid overload has been closely linked with …

Sarcopenic obesity versus nonobese sarcopenia in hemodialysis patients: differences in nutritional status, quality of life, and clinical outcomes

I Beberashvili, A Azar, A Khatib, RA Hamad… - Journal of Renal …, 2023 - Elsevier
Objective Sarcopenia and sarcopenic obesity (SO) are linked to unfavorable prognosis in
maintenance hemodialysis (MHD) populations. We tested whether nonobese sarcopenia …

Cardiovascular biomarkers in chronic kidney disease: state of current research and clinical applicability

L D'Marco, A Bellasi, P Raggi - Disease markers, 2015 - Wiley Online Library
The high incidence of cardiovascular events in chronic kidney disease (CKD) warrants an
accurate evaluation of risk aimed at reducing the burden of disease and its consequences …

Geriatric nutritional risk index, muscle function, quality of life and clinical outcome in hemodialysis patients

I Beberashvili, A Azar, I Sinuani, G Shapiro, L Feldman… - Clinical nutrition, 2016 - Elsevier
Background & aims The geriatric nutritional risk index (GNRI) has been reported as a useful
predictor of prognosis in maintenance hemodialysis (MHD) patients, demonstrating GNRI …

[HTML][HTML] Hyperleptinemia is associated with impaired pulmonary host defense

NDJ Ubags, RD Stapleton, JHJ Vernooy, E Burg… - JCI insight, 2016 - ncbi.nlm.nih.gov
We have previously reported that obesity attenuates pulmonary inflammation in both
patients with acute respiratory distress syndrome (ARDS) and in mouse models of the …

Longitudinal changes in bioimpedance phase angle reflect inverse changes in serum IL-6 levels in maintenance hemodialysis patients

I Beberashvili, A Azar, I Sinuani, H Kadoshi, G Shapiro… - Nutrition, 2014 - Elsevier
Objective We hypothesize that longitudinal changes in phase angle (PA) have independent
associations with changes in inflammatory parameters over time and consequently with long …

Epicardial adipose tissue, adiponectin and leptin: a potential source of cardiovascular risk in chronic kidney disease

L D'Marco, MJ Puchades, JL Gorriz… - International Journal of …, 2020 - mdpi.com
The importance of cardiometabolic factors in the inception and progression of
atherosclerotic cardiovascular disease is increasingly being recognized. Beyond diabetes …

Leptin Levels and Appetite Score in Patients on Hemodialysis Using High Flux or Medium Cutoff Membranes

RG Armani, L da Silva, AB Carvalho, S Manfredi… - Journal of Renal …, 2023 - Elsevier
Objectives Chronic kidney disease (CKD) patients on hemodialysis may have a modified
appetite due to several factors including a lack of uremic toxins elimination. The use of …