Role of inactivity in chronic diseases: evolutionary insight and pathophysiological mechanisms

FW Booth, CK Roberts, JP Thyfault… - Physiological …, 2017 - journals.physiology.org
This review proposes that physical inactivity could be considered a behavior selected by
evolution for resting, and also selected to be reinforcing in life-threatening situations in …

The effects of acute and chronic exercise on skeletal muscle proteome

BA Petriz, CPC Gomes, JA Almeida… - Journal of cellular …, 2017 - Wiley Online Library
Skeletal muscle plasticity and its adaptation to exercise is a topic that is widely discussed
and investigated due to its primary role in the field of exercise performance and health …

[HTML][HTML] Biological/genetic regulation of physical activity level: consensus from GenBioPAC

JT Lightfoot, EJC De Geus, FW Booth… - Medicine and science …, 2018 - ncbi.nlm.nih.gov
PURPOSE: Physical activity unquestionably maintains and improves health; however,
physical activity levels globally are low and not rising despite all the resources devoted to …

[HTML][HTML] The HERITAGE Family Study: a review of the effects of exercise training on cardiometabolic health, with insights into molecular transducers

MA Sarzynski, TK Rice, JP Després… - Medicine and science …, 2022 - ncbi.nlm.nih.gov
The aim of the HERITAGE Family Study was to investigate individual differences in response
to a standardized endurance exercise program, the role of familial aggregation, and the …

Loss-of-function approaches in comparative physiology: is there a future for knockdown experiments in the era of genome editing?

AM Zimmer, YK Pan, T Chandrapalan… - Journal of …, 2019 - journals.biologists.com
Loss-of-function technologies, such as morpholino-and RNAi-mediated gene knockdown,
and TALEN-and CRISPR/Cas9-mediated gene knockout, are widely used to investigate …

Genetics of regular exercise and sedentary behaviors

EJC De Geus, M Bartels, J Kaprio… - Twin Research and …, 2014 - cambridge.org
Studies on the determinants of physical activity have traditionally focused on social factors
and environmental barriers, but recent research has shown the additional importance of …

Inter-individual variation in adaptations to endurance and resistance exercise training: genetic approaches towards understanding a complex phenotype

HL Vellers, SR Kleeberger, JT Lightfoot - Mammalian genome, 2018 - Springer
Exercise training which meets the recommendations set by the National Physical Activity
Guidelines ensues a multitude of health benefits towards the prevention and treatment of …

The Effect of Growth Restriction on Voluntary Physical Activity Engagement in Mice.

EC Leszczynski, JR Visker… - Medicine and Science in …, 2019 - europepmc.org
Methods Using a cross-fostering, protein-restricted nutritive model, mice were growth-
restricted during either gestation (GUN; N= 3 litters) or postnatal life (PUN; N= 3 litters). At 21 …

Postnatal undernutrition in mice causes cardiac arrhythmogenesis which is exacerbated when pharmacologically stressed

JR Visker, DP Ferguson - Journal of Developmental Origins of Health …, 2018 - cambridge.org
Growth restriction caused by postnatal undernutrition increases risk for cardiovascular
disease in adulthood with the potential to induce arrhythmogenesis. Thus, the purpose was …

Differential mi RNA expression in inherently high‐and low‐active inbred mice

M Dawes, KJ Kochan, PK Riggs… - Physiological …, 2015 - Wiley Online Library
Despite established health benefits of regular exercise, the majority of Americans do not
meet the recommended levels of physical activity. While it is known that voluntary activity …