Formation of the 3′ end of a eukaryotic mRNA is a key step in the production of a mature
transcript. This process is mediated by a number of protein factors that cleave the pre …

Alternative cleavage and polyadenylation (APA) is a widespread mechanism to generate
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …

The S9. 6 antibody is broadly used to detect RNA: DNA hybrids but has significant affinity for
double-stranded RNA. The impact of this off-target RNA binding activity has not been …

Cleavage and polyadenylation (CPA) is responsible for 3′ end processing of eukaryotic
poly (A)+ RNAs and preludes transcriptional termination. JTE-607, which targets CPSF-73 …

The use of photo-affinity reagents for the mapping of noncovalent small molecule–protein
interactions has become widespread. Recently, several 'fully-functionalized'(FF) chemical …

Abstract 3′ end processing of most human mRNAs is carried out by the cleavage and
polyadenylation specificity factor (CPSF; CPF in yeast). Endonucleolytic cleavage of the …

Lack of cellular differentiation is a hallmark of many human cancers, including acute myeloid
leukemia (AML). Strategies to overcome such a differentiation blockade are an approach for …

Transcriptional dysregulation is a recurring pathogenic hallmark and an emerging
therapeutic vulnerability in ovarian cancer. Here, we demonstrated that ovarian cancer …

Introduction Chagas disease (CD) imposes social and economic burdens, yet the available
treatments have limited efficacy in the disease's chronic phase and cause serious adverse …

Dysregulation of the flow of information from genomic DNA to RNA to protein occurs within
all cancer types. In this review, we described the current state of understanding of how RNA …