The functions, purposes, and roles of metallothioneins have been the subject of
speculations since the discovery of the protein over 60 years ago. This article guides …

Free radicals are chemical particles containing one or more unpaired electrons, which may
be part of the molecule. They cause the molecule to become highly reactive. The free …

Selenium (Se)-containing compounds have emerged as potential therapeutic agents for the
treatment of a range of diseases. Through tremendous effort, considerable knowledge has …

The solution and complexation chemistry of zinc ions is the basis for zinc biology. In living
organisms, zinc is redox-inert and has only one valence state: Zn (II). Its coordination …

Background With cancer cells encompassing consistently higher production of reactive
oxygen species (ROS) and with an induced antioxidant defense to counteract the increased …

The biological activity of selenium is dependent upon its speciation. We aim to integrate
selenium speciation and metabolism into a discussion of the mechanisms by which …

Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …

Recent discoveries in zinc biology provide a new platform for discussing the primary
physiological functions of mammalian metallothioneins (MTs) and their exquisite zinc …

Zinc (II) ions are redox-inert in biology. Yet, their interaction with sulfur of cysteine in cellular
proteins can confer ligand-centered redox activity on zinc coordination sites, control protein …

The brain is a singular organ of unique biological complexity that serves as the command
center for cognitive and motor function. As such, this specialized system also possesses a …