RASSF1A (Ras association domain family 1 isoform A) is a recently discovered tumor
suppressor whose inactivation is implicated in the development of many human cancers …

The Ras-Association Domain Family (RASSF) comprises ten members, termed RASSF1 to
RASSF10. RASSF1 to RASSF6 harbor a C-terminal Ras-association (RA) domain and …

RASSF1A is a tumor suppressor gene that is epigenetically silenced in a wide variety of
sporadic human malignancies. Expression of alternative RASSF1 isoforms cannot substitute …

Ras proteins play a direct causal role in human cancer with activating mutations in Ras
occurring in∼ 30% of tumours. Ras effectors also contribute to cancer, as mutations occur in …

Abstract Deletions of the 3p21. 3 region are a frequent and early event in the formation of
lung, breast, kidney and other cancers. Intense investigation of allelic losses and the …

Genetic changes through allelic loss and nucleic acid or protein modifications are the main
contributors to loss of function of tumor suppressor proteins. In particular, epigenetic …

Hypoxia signaling plays a major role in non-malignant and malignant hyperproliferative
diseases. Pulmonary hypertension (PH), a hypoxia-driven vascular disease, is characterized …

There are six core RASSF family proteins that contain conserved Ras Association domains
and may serve as Ras effectors. They lack intrinsic enzymatic activity and appear to function …

The Ras association domain family protein1 isoform A (RASSF1A) is a well-known tumor-
suppressor protein frequently inactivated in various human cancers. Consistent with its …

Ras GTPases mediate a wide variety of cellular processes by converting a multitude of
extracellular stimuli into specific biological responses including proliferation, differentiation …