The bright and the dark side of human antibody responses to flaviviruses: lessons for vaccine design

FA Rey, K Stiasny, MC Vaney, M Dellarole… - EMBO reports, 2018 - embopress.org
Zika and dengue viruses belong to the Flavivirus genus, a close group of antigenically
related viruses that cause significant arthropod‐transmitted diseases throughout the globe …

A review on dengue vaccine development

SQ Deng, X Yang, Y Wei, JT Chen, XJ Wang, HJ Peng - Vaccines, 2020 - mdpi.com
Dengue virus (DENV) has become a global health threat with about half of the world's
population at risk of infection. Although the disease caused by DENV is self-limiting in the …

A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate

L Sanchez-Felipe, T Vercruysse, S Sharma, J Ma… - Nature, 2021 - nature.com
The expanding pandemic of coronavirus disease 2019 (COVID-19) requires the
development of safe, efficacious and fast-acting vaccines. Several vaccine platforms are …

Immunoinformatics design of a novel epitope-based vaccine candidate against dengue virus

AO Fadaka, NRS Sibuyi, DR Martin, M Goboza… - Scientific reports, 2021 - nature.com
Dengue poses a global health threat, which will persist without therapeutic intervention.
Immunity induced by exposure to one serotype does not confer long-term protection against …

The present and future of yellow fever vaccines

CA Hansen, ADT Barrett - Pharmaceuticals, 2021 - mdpi.com
The disease yellow fever (YF) is prevented by a live-attenuated vaccine, termed 17D, which
has been in use since the 1930s. One dose of the vaccine is thought to give lifelong (35+ …

Flavivirus: from structure to therapeutics development

R Zhao, M Wang, J Cao, J Shen, X Zhou, D Wang… - Life, 2021 - mdpi.com
Flaviviruses are still a hidden threat to global human safety, as we are reminded by recent
reports of dengue virus infections in Singapore and African-lineage-like Zika virus infections …

Recent developments in recombinant protein–based dengue vaccines

NK Tripathi, A Shrivastava - Frontiers in immunology, 2018 - frontiersin.org
Recombinant proteins are gaining enormous importance these days due to their wide
application as biopharmaceutical products and proven safety record. Various recombinant …

Tick-borne encephalitis virus: A quest for better vaccines against a virus on the rise

M Kubinski, J Beicht, T Gerlach, A Volz, G Sutter… - Vaccines, 2020 - mdpi.com
Tick-borne encephalitis virus (TBEV), a member of the family Flaviviridae, is one of the most
important tick-transmitted viruses in Europe and Asia. Being a neurotropic virus, TBEV …

Recent update on anti-dengue drug discovery

SN Dighe, K Dua, DK Chellappan, PL Katavic… - European journal of …, 2019 - Elsevier
Dengue is the most important arthropod-borne viral disease of humans, with more than half
of the global population living in at-risk areas. Despite the negative impact on public health …

Anti-dengue vaccines: from development to clinical trials

JR Pinheiro-Michelsen, RSO Souza… - Frontiers in …, 2020 - frontiersin.org
Dengue Virus (DENV) is an arbovirus (arthropod-borne virus). Four serotypes of DENV are
responsible for the infectious disease called dengue that annually affects nearly 400 million …