Antiviral drug resistance as an adaptive process

KK Irwin, N Renzette, TF Kowalik, JD Jensen - Virus evolution, 2016 - academic.oup.com
Antiviral drug resistance is a matter of great clinical importance that, historically, has been
investigated mostly from a virological perspective. Although the proximate mechanisms of …

Emerging concepts in congenital cytomegalovirus

MH Pesch, MR Schleiss - Pediatrics, 2022 - publications.aap.org
Over a century of research has focused on improving our understanding of congenital
cytomegalovirus (cCMV), yet it remains the most common congenital infection in the United …

Human cytomegalovirus haplotype reconstruction reveals high diversity due to superinfection and evidence of within-host recombination

J Cudini, S Roy, CJ Houldcroft… - Proceedings of the …, 2019 - National Acad Sciences
Recent sequencing efforts have led to estimates of human cytomegalovirus (HCMV)
genome-wide intrahost diversity that rival those of persistent RNA viruses [Renzette N …

High-risk oncogenic human cytomegalovirus

G Herbein - Viruses, 2022 - mdpi.com
Human cytomegalovirus (HCMV) is a herpesvirus that infects between 40% and 95% of the
population worldwide, usually without symptoms. The host immune response keeps the …

The human cytomegalovirus, from oncomodulation to oncogenesis

G Herbein - Viruses, 2018 - mdpi.com
Besides its well-described impact in immunosuppressed patients, the role of human
cytomegalovirus (HCMV) in the pathogenesis of cancer has been more recently …

Human cytomegalovirus: taking the strain

GWG Wilkinson, AJ Davison, P Tomasec… - Medical microbiology …, 2015 - Springer
In celebrating the 60th anniversary of the first isolation of human cytomegalovirus (HCMV),
we reflect on the merits and limitations of the viral strains currently being used to develop …

Development of a vaccine against human cytomegalovirus: advances, barriers, and implications for the clinical practice

S Scarpini, F Morigi, L Betti, A Dondi, C Biagi, M Lanari - Vaccines, 2021 - mdpi.com
Human cytomegalovirus (hCMV) is one of the most common causes of congenital infection
in the post-rubella era, representing a major public health concern. Although most cases are …

Limits and patterns of cytomegalovirus genomic diversity in humans

N Renzette, C Pokalyuk, L Gibson… - Proceedings of the …, 2015 - National Acad Sciences
Human cytomegalovirus (HCMV) exhibits surprisingly high genomic diversity during natural
infection although little is known about the limits or patterns of HCMV diversity among …

Mouse model of cytomegalovirus disease and immunotherapy in the immunocompromised host: Predictions for medical translation that survived the “test of time”

MJ Reddehase, NAW Lemmermann - Viruses, 2018 - mdpi.com
Human Cytomegalovirus (hCMV), which is the prototype member of the β-subfamily of the
herpesvirus family, is a pathogen of high clinical relevance in recipients of hematopoietic …

Impacts of genome-wide analyses on our understanding of human herpesvirus diversity and evolution

DW Renner, ML Szpara - Journal of virology, 2018 - Am Soc Microbiol
Until fairly recently, genome-wide evolutionary dynamics and within-host diversity were
more commonly examined in the context of small viruses than in the context of large double …