A substantial loss of muscle mass and strength (sarcopenia), a decreased regenerative
capacity, and a compromised physical performance are hallmarks of aging skeletal muscle …

The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 39
2 (SARS-CoV-2) virus, has made a staggering global impact and became one of the most 40 …

Much of the spotlight for coronavirus disease 2019 (COVID-19) is on the acute symptoms
and recovery. However, many recovered patients face persistent physical, cognitive, and …

Peroxisome proliferator–activated receptor-γ coactivator-1α (PGC-1α) is a master regulator
of mitochondrial biogenesis. Reduced PGC-1α abundance is linked to skeletal muscle …

In vitro models of contractile human skeletal muscle hold promise for use in disease
modeling and drug development, but exhibit immature properties compared to native adult …

Skeletal muscle shows high plasticity in response to external demand. Moreover, adult
skeletal muscle is capable of complete regeneration after injury, due to the properties of …

Sarcopenia is of important clinical relevance for loss of independence in older adults. The
prevalence of obesity in combination with sarcopenia ('sarcopenic-obesity') is increasing at …

Sarcopenia is associated with increased levels of apoptosis (47) and reduced capabilities
for muscle regeneration (41) leading to muscle wasting. For this reason, many studies …

Estrogens and androgens influence the growth and maintenance of bones and muscles and
are responsible for their sexual dimorphism. A decline in their circulating levels leads to loss …

Aging is characterized by a progressive decline of physiological integrity leading to the loss
of tissue function and vulnerability to disease, but its causes remain poorly understood …