Iron is an essential cofactor for important biological activities and biochemical reactions,
including the transport of oxygen via red blood cells and its reduction to water during …

Context: The long-lived thyroid cell generates, for the synthesis of thyroid hormones,
important amounts of H2O2 that are toxic in other cell types. This review analyzes the …

Reactive oxygen species (ROS), products of oxidative stress, contribute to the initiation and
progression of the pathogenesis of various diseases. Glutathione is a major antioxidant that …

It is well-recognized that the matrix stiffness as an important stem cell niche can mediate
stem cell behavior such as attachment, proliferation and differentiation, but how matrix …

Hydrogen peroxide is an aerobic metabolite playing a central role in redox signaling and
oxidative stress. H 2 O 2 could activate redox sensitive transcription factors, such as Nrf2, AP …

[Frontiers in Bioscience 13, 5866-5879, May 1, 2008] 5866 MSK activation and physiological
roles J. Simon C. Arthur MRC Protein Page 1 [Frontiers in Bioscience 13, 5866-5879, May 1 …

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear
transcription factors that belong to the nuclear receptor superfamily. Three isoforms of PPAR …

We reveal a novel pro-survival role for mammalian p38α in response to H 2 O 2, which
involves an up-regulation of antioxidant defenses. The presence of p38α increases basal …

Phloroglucinol (PG) is a component of phlorotannins, which are abundant in marine brown
alga species. Recent studies have shown that PG is beneficial in protecting cells from …

Colorectal cancer (CRC) is a globally prevalent malignancy with a high potential for
metastasis. Existing cancer treatments have limitations, including drug resistance and …