New insights in the design of bioactive peptides and chelating agents for imaging and therapy in oncology

AL Tornesello, L Buonaguro, ML Tornesello… - Molecules, 2017 - mdpi.com
Many synthetic peptides have been developed for diagnosis and therapy of human cancers
based on their ability to target specific receptors on cancer cell surface or to penetrate the …

What about αvβ3 integrins in molecular imaging in oncology?

F Debordeaux, L Chansel-Debordeaux… - Nuclear medicine and …, 2018 - Elsevier
Non-invasive investigation of integrin expression is an interesting approach in nuclear
medicine department. Indeed, integrins are overexpressed in a wide array of diseases …

Radiopharmaceuticals for imaging and endoradiotherapy of neurotensin receptor‐positive tumors

S Maschauer, O Prante - Journal of Labelled Compounds and …, 2018 - Wiley Online Library
The neurotensin receptors are overexpressed in various tumor types, especially in highly
progressive pancreatic tumors. As this cancer has a poor 5‐year survival prognosis, there is …

18F- and 68Ga-Labeled Neurotensin Peptides for PET Imaging of Neurotensin Receptor 1

S Maschauer, J Einsiedel, H Hübner… - Journal of Medicinal …, 2016 - ACS Publications
The neurotensin (NT) receptor-1 (NTS1) is overexpressed in a variety of carcinomas and is
therefore an interesting target for imaging with positron emission tomography (PET). The aim …

Development of Radiogallium-Labeled Peptides for Platelet-Derived Growth Factor Receptor β (PDGFRβ) Imaging: Influence of Different Linkers

N Effendi, K Mishiro, K Shiba, S Kinuya, K Ogawa - Molecules, 2020 - mdpi.com
The purpose of this study is to develop peptide-based platelet-derived growth factor receptor
β (PDGFR β) imaging probes and examine the effects of several linkers, namely un-natural …

Rational design of NT-PSMA heterobivalent probes for prostate cancer theranostics

S Previti, S Bodin, E Rémond, D Vimont… - RSC Medicinal …, 2024 - pubs.rsc.org
Targeting the prostate-specific membrane antigen (PSMA) with radiopharmaceuticals for
imaging and/or therapy has demonstrated significant advancement in the management of …

Development of a Neurotensin-Derived 68Ga-Labeled PET Ligand with High In Vivo Stability for Imaging of NTS1 Receptor-Expressing Tumors

L Schindler, J Moosbauer, D Schmidt, T Spruss, L Grätz… - Cancers, 2022 - mdpi.com
Simple Summary Cancer diagnostics based on molecular imaging techniques such as
positron emission tomography (PET) requires radiolabeled tracers, which are taken up by …

An overview of bioactive peptides for in vivo imaging and therapy in human diseases

A Lucia Tornesello, M Lina Tornesello… - Mini reviews in …, 2017 - benthamdirect.com
Background: Radiolabeled peptides, designed to bind with high affinity receptors selectively
expressed on cell membranes of different human tissues, represent valuable tools for in vivo …

[HTML][HTML] New extracellular factors in glioblastoma multiforme development: neurotensin, growth differentiation factor-15, sphingosine-1-phosphate and …

J Korbecki, I Gutowska, I Kojder, D Jeżewski… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Recent years have seen considerable progress in understanding the biochemistry of cancer.
For example, more significance is now assigned to the tumor microenvironment, especially …

Modifications at Arg and Ile Give Neurotensin(8–13) Derivatives with High Stability and Retained NTS1 Receptor Affinity

L Schindler, G Bernhardt, M Keller - ACS Medicinal Chemistry …, 2019 - ACS Publications
Due to its expression in various malignant tumors, the neurotensin receptor 1 (NTS1R) has
been suggested and explored as a target for tumor diagnosis and therapy. Animal model …