New insights into the regulation of HDL metabolism and reverse cholesterol transport

GF Lewis, DJ Rader - Circulation research, 2005 - Am Heart Assoc
The metabolism of high-density lipoproteins (HDL), which are inversely related to risk of
atherosclerotic cardiovascular disease, involves a complex interplay of factors regulating …

High density lipoproteins and arteriosclerosis: role of cholesterol efflux and reverse cholesterol transport

A Von Eckardstein, JR Nofer… - … , thrombosis, and vascular …, 2001 - Am Heart Assoc
High density lipoprotein (HDL) cholesterol is an important risk factor for coronary heart
disease, and HDL exerts various potentially antiatherogenic properties, including the …

Common variants at 30 loci contribute to polygenic dyslipidemia

S Kathiresan, CJ Willer, GM Peloso, S Demissie… - Nature …, 2009 - nature.com
Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol
and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic …

A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism

A Rigotti, BL Trigatti, M Penman… - Proceedings of the …, 1997 - National Acad Sciences
Plasma high density lipoprotein (HDL), which protects against atherosclerosis, is thought to
remove cholesterol from peripheral tissues and to deliver cholesteryl esters via a selective …

Molecular regulation of HDL metabolism and function: implications for novel therapies

DJ Rader - The Journal of clinical investigation, 2006 - Am Soc Clin Investig
HDL metabolism represents a major target for the development of therapies intended to
reduce the risk of atherosclerotic cardiovascular disease. HDL metabolism is complex and …

ATP-binding cassette transporter A1: a cell cholesterol exporter that protects against cardiovascular disease

JF Oram, JW Heinecke - Physiological reviews, 2005 - journals.physiology.org
Blood high-density lipoprotein (HDL) levels are inversely related to risk for cardiovascular
disease, implying that factors associated with HDL metabolism are atheroprotective. One of …

Genetic determinants of plasma triglycerides

CT Johansen, S Kathiresan, RA Hegele - Journal of lipid research, 2011 - ASBMB
Plasma triglyceride (TG) concentration is reemerging as an important cardiovascular
disease risk factor. More complete understanding of the genes and variants that modulate …

Formation and metabolism of prebeta-migrating, lipid-poor apolipoprotein AI

KA Rye, PJ Barter - Arteriosclerosis, thrombosis, and vascular …, 2004 - Am Heart Assoc
The preferred extracellular acceptor of cell phospholipids and unesterified cholesterol in the
process mediated by the ATP-binding cassette A1 (ABCA1) transporter is a monomolecular …

Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels

X Jiang, C Bruce, J Mar, M Lin, Y Ji… - The Journal of …, 1999 - Am Soc Clin Investig
It has been proposed that the plasma phospholipid transfer protein (PLTP) facilitates the
transfer of phospholipids and cholesterol from triglyceride-rich lipoproteins (TRL) into high …

Remodelling of high density lipoproteins by plasma factors

KA Rye, MA Clay, PJ Barter - Atherosclerosis, 1999 - Elsevier
Evidence that the high density lipoproteins (HDL) in human plasma are antiatherogenic has
stimulated considerable interest in the factors which regulate their structure and function …