Gene drives gaining speed

E Bier - Nature Reviews Genetics, 2022 - nature.com
Gene drives are selfish genetic elements that are transmitted to progeny at super-Mendelian
(> 50%) frequencies. Recently developed CRISPR–Cas9-based gene-drive systems are …

Concerning RNA-guided gene drives for the alteration of wild populations

KM Esvelt, AL Smidler, F Catteruccia, GM Church - elife, 2014 - elifesciences.org
Gene drives may be capable of addressing ecological problems by altering entire
populations of wild organisms, but their use has remained largely theoretical due to …

Dual effector population modification gene-drive strains of the African malaria mosquitoes, Anopheles gambiae and Anopheles coluzzii

R Carballar-Lejarazú, Y Dong… - Proceedings of the …, 2023 - National Acad Sciences
Proposed genetic approaches for reducing human malaria include population modification,
which introduces genes into vector mosquitoes to reduce or prevent parasite transmission …

Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi

A Adolfi, VM Gantz, N Jasinskiene, HF Lee… - Nature …, 2020 - nature.com
Abstract Cas9/gRNA-mediated gene-drive systems have advanced development of genetic
technologies for controlling vector-borne pathogen transmission. These technologies …

Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi

VM Gantz, N Jasinskiene… - Proceedings of the …, 2015 - National Acad Sciences
Genetic engineering technologies can be used both to create transgenic mosquitoes
carrying antipathogen effector genes targeting human malaria parasites and to generate …

Vector biology meets disease control: using basic research to fight vector-borne diseases

WR Shaw, F Catteruccia - Nature microbiology, 2019 - nature.com
Human pathogens that are transmitted by insects are a global problem, particularly those
vectored by mosquitoes; for example, malaria parasites transmitted by Anopheles species …

malERA: an updated research agenda for malaria elimination and eradication

RN Rabinovich, C Drakeley, AA Djimde, BF Hall… - PLoS …, 2017 - journals.plos.org
Achieving a malaria-free world presents exciting scientific challenges as well as
overwhelming health, equity, and economic benefits. WHO and countries are setting …

Paratransgenesis: a promising new strategy for mosquito vector control

ABB Wilke, MT Marrelli - Parasites & vectors, 2015 - Springer
The three main mosquito genera, Anopheles, Aedes and Culex, transmit respectively
malaria, dengue and lymphatic filariasis. Current mosquito control strategies have proved …

Advances in engineering the fly genome with the CRISPR-Cas system

E Bier, MM Harrison, KM O'Connor-Giles… - Genetics, 2018 - academic.oup.com
Drosophila has long been a premier model for the development and application of cutting-
edge genetic approaches. The CRISPR-Cas system now adds the ability to manipulate the …

Experimental population modification of the malaria vector mosquito, Anopheles stephensi

TB Pham, CH Phong, JB Bennett, K Hwang… - PLoS …, 2019 - journals.plos.org
Small laboratory cage trials of non-drive and gene-drive strains of the Asian malaria vector
mosquito, Anopheles stephensi, were used to investigate release ratios and other strain …