The recent surge of interest in metal-catalysed C–H bond functionalisation reactions reflects
the importance of such reactions in biomimetic studies and organic synthesis. This critical …

Cytochrome P450 is one of the most versatile enzymes in nature. 1 It uses dioxygen and two
reducing equivalents to catalyze a great variety of stereospecific and regioselective oxygen …

Following the heme paradigm, it is often proposed that dioxygen activation by nonheme
monoiron enzymes involves an iron (IV)= oxo intermediate that is responsible for the …

As the main constituent of natural gas, alkanes are arguably Nature's most plentiful organic
base chemicals that are easily accessible. Chemists have long coveted the use of alkanes …

Oxidations are key reactions in chemical syntheses. Biooxidations using fermentation
processes have already conquered some niches in industrial oxidation processes since they …

The stereospecific cytochrome P450-catalyzed hydroxylation of the C5− H (5-exo) bond in
camphor has been studied theoretically by a combined quantum mechanical/molecular …

Mechanistic and energetic aspects for the conversion of camphor to 5-exo-hydroxycamphor
by the compound I iron-oxo species of cytochrome P450 are discussed from B3LYP DFT …

Anaerobic oxidations of 9, 10-dihydroanthracene (DHA), xanthene, and fluorene by [(bpy) 2
(py) RuIVO] 2+ in acetonitrile solution give mixtures of products including oxygenated and …

Human cytochromes P450 play a vital role in drug metabolism. The key step in substrate
oxidation involves hydrogen atom abstraction or CC bond addition by the oxygen atom of …

Norcarane (1) and spiro [2.5] octane (2) yield different product distributions depending on
whether they are oxidized via concerted, radical, or cationic mechanisms. For this reason …