Mechanisms and regulation of defensins in host defense

J Fu, X Zong, M Jin, J Min, F Wang… - Signal Transduction and …, 2023 - nature.com
As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth
cells, neutrophils, and epithelial cells, contributing to host defense. Their biological functions …

The dual role of antimicrobial peptides in autoimmunity

W Liang, J Diana - Frontiers in immunology, 2020 - frontiersin.org
Autoimmune diseases (AiDs) are characterized by the destruction of host tissues by the host
immune system. The etiology of AiDs is complex, with the implication of multiple genetic …

Antimicrobial host defence peptides: immunomodulatory functions and translational prospects

AM van der Does, PS Hiemstra… - … Peptides: Basics for …, 2019 - Springer
Cationic host defence peptides (CHDPs), also known as antimicrobial peptides, exhibit a
wide range of activities contributing to immune responses and resolution of infections …

Inflammation and vascular dysfunction: The negative synergistic combination of diabetes and COVID‐19

AM Bolla, C Loretelli, L Montefusco… - Diabetes/Metabolism …, 2022 - Wiley Online Library
Aims Several reports indicate that diabetes determines an increased mortality risk in patients
with coronavirus disease 19 (COVID‐19) and a good glycaemic control appears to be …

T2DiACoD: a gene atlas of type 2 diabetes mellitus associated complex disorders

J Rani, I Mittal, A Pramanik, N Singh, N Dube… - Scientific reports, 2017 - nature.com
We performed integrative analysis of genes associated with type 2 Diabetes Mellitus (T2DM)
associated complications by automated text mining with manual curation and also gene …

Meta-analysis of Parkinson's disease Transcriptome data using TRAM software: whole Substantia Nigra tissue and single dopamine neuron differential gene …

E Mariani, F Frabetti, A Tarozzi, MC Pelleri, F Pizzetti… - PLoS …, 2016 - journals.plos.org
The understanding of the genetic basis of the Parkinson's disease (PD) and the correlation
between genotype and phenotype has revolutionized our knowledge about the …

Genetic and familial predisposition to rotator cuff disease: a systematic review

DI Dabija, C Gao, TL Edwards, JE Kuhn… - Journal of shoulder and …, 2017 - Elsevier
Background Rotator cuff disease is a common disorder leading to shoulder pain and loss of
function. Its etiology in atraumatic cases is uncertain and is likely to extend beyond repetitive …

Altered expression of antimicrobial peptides in the upper gastrointestinal tract of patients with diabetes mellitus

O Linn, B Menges, F Lammert, SN Weber, M Krawczyk - Nutrients, 2023 - mdpi.com
Antimicrobial peptides (AMP) are essential components of innate immunity with a broad
range of antimicrobial activities against bacteria, viruses, and fungi. The aim of this study …

Human β-defensin 1 update: Potential clinical applications of the restless warrior

ÁH Álvarez, MM Velázquez, EPM de Oca - The International Journal of …, 2018 - Elsevier
Abstract Human β-defensin 1 (hBD-1) is a multifaceted antimicrobial peptide being a tumour
suppressor and, depending on call of duty, capable of inducing self-nets and neutrophil …

Antimicrobial peptides as a possible interlink between periodontal diseases and its risk factors: a systematic review

S Li, G Schmalz, J Schmidt, F Krause… - Journal of …, 2018 - Wiley Online Library
Antimicrobial peptides (AMPs) play a critical role in controlling innate and acquired immune
responses. Local dysregulation of AMP is implicated in the pathogenesis of periodontal …