Platycodon grandiflorus–An ethnopharmacological, phytochemical and pharmacological review

L Zhang, Y Wang, D Yang, C Zhang, N Zhang… - Journal of …, 2015 - Elsevier
Abstract Ethnopharmacological relevance Platycodon grandiflorus (Jacq.) A. DC., the sole
species in genus Platycodon A. DC.(Campanulaceae) has a long history of use as a …

The importance of transmission electron microscopy analysis of spermatozoa: Diagnostic applications and basic research

E Moretti, G Sutera, G Collodel - Systems biology in reproductive …, 2016 - Taylor & Francis
This review is aimed at discussing the role of ultrastructural studies on human spermatozoa
and evaluating transmission electron microscopy as a diagnostic tool that can complete …

Platycodin D alleviates liver fibrosis and activation of hepatic stellate cells by regulating JNK/c-JUN signal pathway

Y Liu, S Cong, Z Cheng, Y Hu, Y Lei, L Zhu… - European Journal of …, 2020 - Elsevier
Liver fibrosis is involved in the progression of most chronic liver diseases. Even though we
have made a huge progress in order to understand the pathogenesis of liver fibrosis …

Sertraline-induced reproductive toxicity in male rats: evaluation of possible underlying mechanisms

O Atli, M Baysal, G Aydogan-Kilic, V Kilic… - Asian journal of …, 2017 - journals.lww.com
This study was conducted to clarify the toxic effects of sertraline (SRT) on the reproductive
system of male rats and to elucidate the underlying mechanisms. Rats were treated orally …

Rapid characterization of chemical constituents of Platycodon grandiflorum and its adulterant Adenophora stricta by UPLC‐QTOF‐MS/MS

C Wang, N Zhang, Z Wang, Z Qi… - Journal of Mass …, 2017 - Wiley Online Library
Platycodon grandiflorum (PG) is extensively used for treating cough, excessive phlegm, sore
throat, bronchitis and asthma, whereas Adenophora stricta (AS) is commonly used to reduce …

Protective effect of triterpenes against diabetes-induced β-cell damage: An overview of in vitro and in vivo studies

SE Mabhida, PV Dludla, R Johnson, M Ndlovu… - Pharmacological …, 2018 - Elsevier
Accumulative evidence shows that chronic hyperglycaemia is a major factor implicated in
the development of pancreatic β-cell dysfunction in diabetic patients. Furthermore, most of …

Combined anti-cancer effects of platycodin D and sorafenib on androgen-independent and PTEN-deficient prostate cancer

Z Lu, W Song, Y Zhang, C Wu, M Zhu, H Wang… - Frontiers in …, 2021 - frontiersin.org
Castration-resistant (androgen-independent) and PTEN-deficient prostate cancer is a
challenge in clinical practice. Sorafenib has been recommended for the treatment of this …

The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus

L Xie, YX Zhao, Y Zheng, XF Li - Frontiers in Pharmacology, 2023 - frontiersin.org
Chinese doctors widely prescribed Platycodon grandiflorus A. DC.(PG) to treat lung
carbuncles in ancient China. Modern clinical experiences have demonstrated that PG plays …

Proposed mechanisms for the extracellular release of PD-L1 by the anticancer saponin platycodin D

C Bailly, G Vergoten - International Immunopharmacology, 2020 - Elsevier
Platycodin D (PTD) is an oleanane-type terpenoid saponin, isolated from the plant
Platycodon grandiflorus. PTD displays multiple pharmacological effects, notably significant …

[HTML][HTML] Platycodin D, a metabolite of Platycodin grandiflorum, inhibits highly metastatic MDA-MB-231 breast cancer growth in vitro and in vivo by targeting the MDM2 …

Y Kong, ZL Lu, JJ Wang, R Zhou, J Guo… - Oncology …, 2016 - spandidos-publications.com
The objective of the present study was to explore the in vitro and in vivo anticancer effects of
Platycodin D (PD), derived from Platycodin grandiflorum, on highly metastatic MDA-MB-231 …