Podocyte aging: why and how getting old matters
The effects of healthy aging on the kidney, and how these effects intersect with
superimposed diseases, are highly relevant in the context of the population's increasing …
superimposed diseases, are highly relevant in the context of the population's increasing …
Podocyte senescence: from molecular mechanisms to therapeutics
Q Zhao, Y Huang, N Fu, C Cui, X Peng, H Kang… - Renal …, 2024 - Taylor & Francis
As an important component of the glomerular filtration membrane, the state of the podocytes
is closely related to kidney function, they are also key cells involved in aging and play a …
is closely related to kidney function, they are also key cells involved in aging and play a …
Danshen injection induces autophagy in podocytes to alleviate nephrotic syndrome via the PI3K/AKT/mTOR pathway
J Chen, S Yuan, J Zhou, X Huang, W Wu, Y Cao, H Liu… - Phytomedicine, 2022 - Elsevier
Background Danshen injection (DSI) is an agent extracted from the Salvia miltiorrhiza
Bunge, a natural drug commonly used to alleviate kidney diseases. However, the material …
Bunge, a natural drug commonly used to alleviate kidney diseases. However, the material …
[HTML][HTML] REST contributes to AKI-to-CKD transition through inducing ferroptosis in renal tubular epithelial cells
S Gong, A Zhang, M Yao, W Xin, X Guan, S Qin, Y Liu… - JCI insight, 2023 - ncbi.nlm.nih.gov
Ischemic-reperfusion injury (IRI) is a major pathogenic factor in acute kidney injury (AKI),
which directly leads to the hypoxic injury of renal tubular epithelial cells (RTECs). Although …
which directly leads to the hypoxic injury of renal tubular epithelial cells (RTECs). Although …
The transcriptional coactivator Eya1 exerts transcriptional repressive activity by interacting with REST corepressors and REST-binding sequences to maintain nephron …
Eya1 is critical for establishing and maintaining nephron progenitor cells (NPCs). It belongs
to a family of proteins called phosphatase-transcriptional activators but without intrinsic DNA …
to a family of proteins called phosphatase-transcriptional activators but without intrinsic DNA …
Synergistic effects of repeated transcranial magnetic stimulation and mesenchymal stem cells transplantation on alleviating neuroinflammation and PANoptosis in …
S Cheng, Q Lu, Q Liu, Y Ma, J Chen, D Lu… - Journal of …, 2024 - Springer
Background Neuronal death is the primary cause of poor outcomes in cerebral ischemia.
The inflammatory infiltration in the early phase of ischemic stroke plays a vital role in …
The inflammatory infiltration in the early phase of ischemic stroke plays a vital role in …
Tissue-specific expression of senescence biomarkers in spontaneously hypertensive rats: evidence of premature aging in hypertension
R Somsura, K Kamkajon, K Chaimongkolnukul… - PeerJ, 2023 - peerj.com
Background Cellular senescence is an age-related physiological process that contributes to
tissue dysfunction and accelerated onset of chronic metabolic diseases including …
tissue dysfunction and accelerated onset of chronic metabolic diseases including …
Recent Advances in Elucidating the Mechanism Underlying Proteinuric Kidney Disease/Nephrotic Syndrome: Lessons From Knockout/Transgenic Mouse Models
R Saiki, K Katayama, K Dohi - 2023 - preprints.org
Proteinuria is known to be associated with all-cause and cardiovascular mortality, and
nephrotic syndrome is defined by the level of proteinuria and hypoalbuminemia. With …
nephrotic syndrome is defined by the level of proteinuria and hypoalbuminemia. With …
Recent Advances in Proteinuric Kidney Disease/Nephrotic Syndrome: Lessons from Knockout/Transgenic Mouse Models
R Saiki, K Katayama, K Dohi - Biomedicines, 2023 - mdpi.com
Proteinuria is known to be associated with all-cause and cardiovascular mortality, and
nephrotic syndrome is defined by the level of proteinuria and hypoalbuminemia. With …
nephrotic syndrome is defined by the level of proteinuria and hypoalbuminemia. With …