Spatial biology of cancer evolution
Z Seferbekova, A Lomakin, LR Yates… - Nature Reviews …, 2023 - nature.com
The natural history of cancers can be understood through the lens of evolution given that the
driving forces of cancer development are mutation and selection of fitter clones. Cancer …
driving forces of cancer development are mutation and selection of fitter clones. Cancer …
Diagnostic, therapeutic, and prognostic implications of the 2021 World Health Organization classification of tumors of the central nervous system
S Gritsch, TT Batchelor, LN Gonzalez Castro - Cancer, 2022 - Wiley Online Library
The 2016 revised fourth edition of the World Health Organization (WHO) classification of
central nervous system (CNS) tumors incorporated molecular features with histologic …
central nervous system (CNS) tumors incorporated molecular features with histologic …
Glioma progression is shaped by genetic evolution and microenvironment interactions
The factors driving therapy resistance in diffuse glioma remain poorly understood. To identify
treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA …
treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA …
[HTML][HTML] Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma
T Hara, R Chanoch-Myers, ND Mathewson, C Myskiw… - Cancer cell, 2021 - cell.com
The mesenchymal subtype of glioblastoma is thought to be determined by both cancer cell-
intrinsic alterations and extrinsic cellular interactions, but remains poorly understood. Here …
intrinsic alterations and extrinsic cellular interactions, but remains poorly understood. Here …
T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10
Despite recent advances in cancer immunotherapy, certain tumor types, such as
Glioblastomas, are highly resistant due to their tumor microenvironment disabling the anti …
Glioblastomas, are highly resistant due to their tumor microenvironment disabling the anti …
Applications of single-cell sequencing in cancer research: progress and perspectives
Y Lei, R Tang, J Xu, W Wang, B Zhang, J Liu… - Journal of hematology & …, 2021 - Springer
Single-cell sequencing, including genomics, transcriptomics, epigenomics, proteomics and
metabolomics sequencing, is a powerful tool to decipher the cellular and molecular …
metabolomics sequencing, is a powerful tool to decipher the cellular and molecular …
Single-cell landscape of immunological responses in patients with COVID-19
Abstract In coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection, the relationship between disease severity …
syndrome coronavirus 2 (SARS-CoV-2) infection, the relationship between disease severity …
Microglia and central nervous system–associated macrophages—from origin to disease modulation
The immune system of the central nervous system (CNS) consists primarily of innate
immune cells. These are highly specialized macrophages found either in the parenchyma …
immune cells. These are highly specialized macrophages found either in the parenchyma …
Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma
Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal
diversity and dynamic adaptation amid developmental hierarchies. The source of dynamic …
diversity and dynamic adaptation amid developmental hierarchies. The source of dynamic …
Single-cell analyses inform mechanisms of myeloid-targeted therapies in colon cancer
Single-cell RNA sequencing (scRNA-seq) is a powerful tool for defining cellular diversity in
tumors, but its application toward dissecting mechanisms underlying immune-modulating …
tumors, but its application toward dissecting mechanisms underlying immune-modulating …