Curcumin-loaded chitosan nanoparticles alleviate fenpropathrin-induced hepatotoxicity by regulating lipogenesis and pyroptosis in rats

LS Alqahtani, YM Abd-Elhakim, AAR Mohamed… - Food and Chemical …, 2023 - Elsevier
In this study, the probable alleviative role of curcumin (CMN)(50 mg/kg b. wt) or curcumin-
loaded chitosan nanoparticle (CLC-NP)(50 mg/kg b. wt) was assessed against the …

Protective Effect of Honey and Propolis against Gentamicin‐Induced Oxidative Stress and Hepatorenal Damages

H Laaroussi, M Bakour, D Ousaaid… - Oxidative medicine …, 2021 - Wiley Online Library
Bee products are a promising source of phenolic compounds with strong antioxidant activity.
The present study was designed to explore the protective effect of honey, propolis, and their …

Toll-like receptors and nuclear factor kappa B signaling pathway involvement in hepatorenal oxidative damage induced by some food preservatives in rats

YM Abd-Elhakim, A Behairy, MMM Hashem… - Scientific Reports, 2023 - nature.com
Chemical food preservatives are extensively found in various processed food products in the
human environment. Hence, this study aimed to investigate the effect of long-term exposure …

Mancozeb-induced hepatotoxicity: protective role of curcumin in rat animal model

JS Aprioku, AM Amamina… - Toxicology Research, 2023 - academic.oup.com
Background Mancozeb—a widely used fungicide in the agricultural sector—is believed to
cause toxicity by increasing oxidative stress. This work investigated the efficacy of curcumin …

Hepato-renal protective impact of nanocapsulated Petroselinum crispum and Anethum graveolens essential oils added in fermented milk against some food additives …

RS Mohamed, K Fouda, AS Maghraby, FM Assem… - Heliyon, 2024 - cell.com
The study assessed the efficacy of parsley and dill essential oils (EOs) nanocapsules
incorporated into fermented milk in hepato-renal protection against specific food additives. A …

Effect of co-administration of curcumin with amlodipine in hypertension

S Lee, C Jo, HY Choi, K Lee - Nutrients, 2021 - mdpi.com
Curcumin, a curcuminoid known as the main bioactive compound of turmeric, is used in
foods, cosmetics, and pharmaceutical products. Amlodipine is a general antihypertensive …

The interplay of oxidative stress, apoptotic signaling, and impaired mitochondrial function in the pyrethroid-induced cardiac injury: Alleviative role of curcumin-loaded …

AS Alhegaili, DA Bafail, AA Bawahab… - Food and Chemical …, 2024 - Elsevier
This study assessed the consequence of exposure to a pyrethroid insecticide, fenpropathrin
(FPN), on the heart and the probable underlying mechanisms in rats. Moreover, the …

The ameliorative effect of curcumin on hepatic CYP1A1 and CYP1A2 genes dysregulation and hepatorenal damage induced by fenitrothion oral intoxication in male …

YM Abd-Elhakim, GG Moustafa, NI El-Sharkawy… - Pesticide Biochemistry …, 2021 - Elsevier
This research aimed to assess curcumin (CUR) effects on fenitrothion (FNT), a broad-
spectrum organophosphate insecticide,− induced hepatorenal damage. Thirty adult male …

Pumpkin seed oil lessens the colchicine-induced altered sex male hormone balance, testicular oxidative status, sperm abnormalities, and collagen deposition in male …

YM Abd-Elhakim, SS Abd El-Fatah, A Behairy… - Food and Chemical …, 2024 - Elsevier
This study examined the efficiency of pumpkin seed oil (PSO) to rescue the colchicine (CHC)-
induced adverse impacts on sperm characteristics, male sex hormones, testicular …

Curcumin mitigates gentamicin induced-renal and cardiac toxicity via modulation of Keap1/Nrf2, NF-κB/iNOS and Bcl-2/BAX pathways

S Hamdy, GE Elshopakey, EF Risha, S Rezk… - Food and Chemical …, 2024 - Elsevier
Gentamicin (GEN) is an aminoglycoside antibiotic used to treat gram-negative bacterial
infections. Our study aimed to explore curcumin's (CMN) protective role against GEN …