Neutrophils play a critical role in the host defense against bacterial and fungal infections, but
their inappropriate activation also contributes to tissue damage during autoimmune and …

Abstract Src homology-2 (SH2) domain-containing phosphatases (Shps) are a small, highly
conserved subfamily of protein-tyrosine phosphatases, members of which are present in …

Abstract Autophagy-related gene (Atg) 5 is a gene product required for the formation of
autophagosomes. Here, we report that Atg5, in addition to the promotion of autophagy …

Abstract CD95 (APO-1/Fas) is a prototype death receptor characterized by the presence of
an 80 amino acid death domain in its cytoplasmic tail. This domain is essential for the …

Neutrophils, eosinophils, and basophils play essential roles during microbe-induced and
sterile inflammation. The severity of such inflammatory processes is controlled, at least in …

Pre–B cell colony-enhancing factor (PBEF) is a highly conserved 52-kDa protein, originally
identified as a growth factor for early stage B cells. We show here that PBEF is also …

Receptors carrying immunoreceptor tyrosine‐based inhibition motifs (ITIMs) in their
cytoplasmic tail control a vast array of cellular responses, ranging from autoimmunity …

Inhibitory leukocyte immunoglobulin-like receptors (LILRBs 1-5) transduce signals via
intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that recruit protein …

Since an immunoreceptor tyrosine‐based inhibition motif (ITIM) was first identified in the
intracytoplasmic domain of FcγRIIB, ITIMs have been found in a large number of inhibitory …

Analyses of neutrophil death mechanisms have revealed many similarities with other cell
types; however, a few important molecular features make these cells unique executors of …