The evolution of AMPK and its homologs enabled exquisite responsivity and control of
cellular energetic homeostasis. Recent work has been critical in establishing the …

Cancer is characterized as a complex disease caused by coordinated alterations of multiple
signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined …

One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-
activated protein kinase (AMPK), which is activated when intracellular ATP production …

Nrf2 (nuclear factor erythroid 2-related factor 2) is an antioxidant transcription factor. AMP-
activated protein kinase (AMPK) functions as a central regulator of cell survival in response …

All living organisms depend on dynamic mechanisms that repeatedly reassess the status of
amassed energy, in order to adapt energy supply to demand. The AMP-activated protein …

The AMP-activated protein kinase (AMPK) is a key regulator of catabolic versus anabolic
processes. Its properties as an energy sensor allow it to couple the energy status of the cell …

Much attention has recently been focussed on the lysosome as a signalling hub. Following
the initial discovery that localisation of the nutrient-sensitive kinase, mammalian target of …

Aim/hypothesis The glucose-lowering drug metformin has been shown to activate hepatic
AMP-activated protein kinase (AMPK), a master kinase regulating cellular energy …

Pulmonary cavities, the hallmark of tuberculosis (TB), are characterized by high
mycobacterial load and perpetuate the spread of M. tuberculosis. The mechanism of matrix …

Many mutant p53 proteins (mutp53s) exert oncogenic gain-of-function (GOF) properties, but
the mechanisms mediating these functions remain poorly defined. We show here that GOF …