Mycobacterium tuberculosis, which is the aetiological agent of tuberculosis, owes much of its
success as a pathogen to its unique cell wall and unusual mechanism of growth, which …

Tuberculosis (TB) caused by the intracellular pathogen, Mycobacterium tuberculosis (Mtb),
claims more than 1.5 million lives worldwide annually. Despite promulgation of multipronged …

The success of Mycobacterium tuberculosis (Mtb) is largely attributed to its ability to
physiologically adapt and withstand diverse localized stresses within host …

Pathogenic microorganisms encounter a variety of environmental stresses following
infection of their respective hosts. Mycobacterium tuberculosis, the etiological agent of …

Replication of the bacterial chromosome initiates at a single origin of replication that is
called oriC. This occurs via the concerted action of numerous proteins, including DnaA …

The prevalence of antimicrobial-resistant pathogens significantly limited the number of
effective antibiotics available clinically, which urgently requires new drug targets to screen …

Two‐component regulatory systems (2CRSs) are key players in bacterial responses to
changing environments (1, 2). These systems act to integrate multiple stimuli into …

Tuberculosis (TB) is one of the primary causes of deaths due to infectious diseases. The
current TB regimen is long and complex, failing of which leads to relapse and/or the …

Regulating responses to stress is critical for all bacteria, whether they are environmental,
commensal, or pathogenic species. For pathogenic bacteria, successful colonization and …

During the cell division cycle of all bacteria, DNA-protein complexes termed orisomes trigger
the onset of chromosome duplication. Orisome assembly is both staged and stringently …