[HTML][HTML] Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation

TT Wei, M Chandy, M Nishiga, A Zhang, KK Kumar… - Cell, 2022 - cell.com
Epidemiological studies reveal that marijuana increases the risk of cardiovascular disease
(CVD); however, little is known about the mechanism. Δ 9-tetrahydrocannabinol (Δ 9-THC) …

In vivo targeting of CXCR4—new horizons

M Schottelius, K Herrmann, C Lapa - Cancers, 2021 - mdpi.com
Simple Summary Beyond its pre-eminent role in the context of tumor cell growth as well as
metastasis, the CXC motif chemokine receptor 4 (CXCR4) is a key player in the …

CXCR4/CXCL12 axis:“old” pathway as “novel” target for anti‐inflammatory drug discovery

L Lu, J Li, X Jiang, R Bai - Medicinal Research Reviews, 2024 - Wiley Online Library
Inflammation is the body's defense response to exogenous or endogenous stimuli, involving
complex regulatory mechanisms. Discovering anti‐inflammatory drugs with both …

[HTML][HTML] Research progress of CXCR4-targeting radioligands for oncologic imaging

Y Wang, F Gao - Korean Journal of Radiology, 2023 - ncbi.nlm.nih.gov
CXC motif chemokine receptor 4 (CXCR4) plays a key role in various physiological
functions, such as immune processes and disease development, and can influence …

Role and implications of the CXCL12/CXCR4/CXCR7 axis in atherosclerosis: still a debate

HAS Murad, MM Rafeeq, TMA Alqurashi - Annals of medicine, 2021 - Taylor & Francis
Atherosclerosis is one of the leading causes of mortality and morbidity worldwide.
Chemokines and their receptors are implicated in the pathogenesis of atherosclerosis …

Multitargeted Immunomodulatory Therapy for Viral Myocarditis by Engineered Extracellular Vesicles

W Pei, Y Zhang, X Zhu, C Zhao, X Li, H Lü, K Lv - ACS nano, 2024 - ACS Publications
Immune regulation therapies are considered promising for treating classically activated
macrophage (M1)-driven viral myocarditis (VM). Alternatively, activated macrophage (M2) …

Key chemokine pathways in atherosclerosis and their therapeutic potential

AB Márquez, EPC van der Vorst, SL Maas - Journal of Clinical Medicine, 2021 - mdpi.com
The search to improve therapies to prevent or treat cardiovascular diseases (CVDs) rages
on, as CVDs remain a leading cause of death worldwide. Here, the main cause of CVDs …

Imaging Inflammation in Atherosclerosis with CXCR4-Directed [68Ga]PentixaFor PET/MRI—Compared with [18F]FDG PET/MRI

X Lu, R Calabretta, W Wadsak, AR Haug… - Life, 2022 - mdpi.com
(1) This study compared [68Ga] PentixaFor uptake in active arterial segments with
corresponding [18F] FDG arterial uptake as well as the relationship with cardiac [68Ga] …

Uncovering atherosclerotic cardiovascular disease by PET imaging

A Maier, AJP Teunissen, SA Nauta, E Lutgens… - Nature Reviews …, 2024 - nature.com
Assessing atherosclerosis severity is essential for precise patient stratification. Specifically,
there is a need to identify patients with residual inflammation because these patients remain …

Development of a CD163-targeted pet radiotracer that images resident macrophages in atherosclerosis

X Zhang, GS Heo, A Li, D Lahad… - Journal of Nuclear …, 2024 - Soc Nuclear Med
Tissue-resident macrophages are complementary to proinflammatory macrophages to
promote the progression of atherosclerosis. The noninvasive detection of their presence and …