The progression of cardiovascular research is often impeded by the lack of reliable disease
models that fully recapitulate the pathogenesis in humans. These limitations apply to both in …

Precise control of gene expression is crucial to ensure proper development and biological
functioning of an organism. Enhancers are non-coding DNA elements which play an …

Mammalian cardiomyocytes exit the cell cycle shortly after birth. As a result, an occurrence of
coronary occlusion-induced myocardial infarction often results in heart failure, postinfarction …

Organogenesis involves dynamic regulation of gene transcription and complex
multipathway interactions. Despite our knowledge of key factors regulating various steps of …

The adult mammalian cardiomyocyte has a very limited capacity to reenter the cell cycle and
advance into mitosis. Therefore, diseases characterized by lost contractile tissue usually …

Congenital heart disease (CHD) affects approximately 1% of live births worldwide, making it
the most common congenital anomaly in newborns. Recent advancements in genetics and …

Excitation–contraction (EC) coupling in the heart has, until recently, been solely accredited
to cardiomyocytes. The inherent complexities of the heart make it difficult to examine non …

Heart formation in the zebrafish involves a rapid, complex series of morphogenetic events in
three-dimensional space that spans cardiac lineage specification through to chamber …

The transcriptional complexity generated by the human genomic output is within the core of
cell and organ physiology, but also could be in the origin of pathologies. In cardiovascular …

Background Although most cases of atrial septal defect (ASD) are sporadic, familial cases
have been reported, which may be caused by mutation of transcription factor GATA binding …