Acidosis is a well recognised consequence of myocardial ischaemia. In this brief article we
have reviewed the consequences of acidosis that might be arrhythmogenic. These include …

Analysis of the effects of changes in rate and rhythm upon electrical activity in the heart -
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1. The properties of the 'pace‐maker'current iK2 of Purkinje fibres are investigated to verify
whether its behaviour during voltage‐clamp pulses is consistent with the view that iK2 is a K …

We studied the individual and combined effects of extracellular acidosis and increases in
extracellular potassium on action potential characteristics and conduction in order to gain a …

Metabolic acidosis was one of the earliest complications to be recognized and explained
pathologically in patients with CKD. Despite the accumulated evidence of deleterious effects …

Metabolic acidosis is a common complication associated with progressive loss of kidney
function. The diminishing ability of the kidneys to maintain acid–base homeostasis results in …

A stable volume and composition of extracellular fluid are essential for normal functioning of
the body. Since the kidney is primarily responsible for regulating extracellular fluid, loss of …

1. Ischaemia was simulated in the isolated sheep cardiac Purkinje fibre and guinea‐pig
papillary muscle by immersing the preparations in paraffin oil. Ion‐selective microelectrodes …

Background Low serum bicarbonate level is associated with increased mortality, but its role
as a predictor of cardiovascular disease (CVD) is unclear. This study evaluates the …

The contractility of heart muscle is sensitive to small and physiological changes of
extracellular pH. The reduction of contractility associated with an acidosis is determined by …