Acute graft-versus-host disease: from the bench to the bedside

G Socié, BR Blazar - Blood, The Journal of the American …, 2009 - ashpublications.org
During the past decade, progress in basic immunology has been impressive. In parallel,
whereas our understanding of the pathophysiology of acute graft-versus-host disease …

Minor histocompatibility antigens: past, present, and future

E Spierings - Tissue Antigens, 2014 - Wiley Online Library
Minor histocompatibility (H) antigens are key molecules driving allo‐immune responses in
both graft‐versus‐host‐disease (GvHD) and in graft‐versus‐leukemia (GvL) reactivity in …

Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens

EH Warren, N Fujii, Y Akatsuka… - Blood, The Journal …, 2010 - ashpublications.org
The adoptive transfer of donor T cells that recognize recipient minor histocompatibility
antigens (mHAgs) is a potential strategy for preventing or treating leukemic relapse after …

Exploiting T cells specific for human minor histocompatibility antigens for therapy of leukemia

M Bleakley, SR Riddell - Immunology and cell biology, 2011 - Wiley Online Library
Minor histocompatibility (H) antigens are major targets of a graft‐versus‐leukemia (GVL)
effect mediated by donor CD8+ and CD4+ T cells following allogeneic hematopoietic cell …

Autosomal minor histocompatibility antigens: how genetic variants create diversity in immune targets

M Griffioen, CAM van Bergen… - Frontiers in …, 2016 - frontiersin.org
Allogeneic stem cell transplantation (alloSCT) can be a curative treatment for hematological
malignancies. Unfortunately, the desired anti-tumor or graft-versus-leukemia (GvL) effect is …

[HTML][HTML] NCI first international workshop on the biology, prevention, and treatment of relapse after allogeneic hematopoietic stem cell transplantation: report from the …

JS Miller, EH Warren, MRM van den Brink, J Ritz… - Biology of Blood and …, 2010 - Elsevier
The success of allogeneic hematopoietic stem cell transplantation (HSCT) depends on the
infusion of benign stem cells as well as lymphocytes capable of participating in a graft …

Effect of MHC and non-MHC donor/recipient genetic disparity on the outcome of allogeneic HCT

EH Warren, XC Zhang, S Li, W Fan… - Blood, The Journal …, 2012 - ashpublications.org
The outcome of allogeneic hematopoietic cell transplantation is influenced by
donor/recipient genetic disparity at loci both inside and outside the MHC on chromosome …

Transplant genetics and genomics

JYC Yang, MM Sarwal - Nature Reviews Genetics, 2017 - nature.com
Ever since the discovery of the major histocompatibility complex, scientific and clinical
understanding in the field of transplantation has been advanced through genetic and …

High-throughput characterization of 10 new minor histocompatibility antigens by whole genome association scanning

CAM Van Bergen, CE Rutten, ED Van Der Meijden… - Cancer research, 2010 - AACR
Patients with malignant diseases can be effectively treated with allogeneic hematopoietic
stem cell transplantation (allo-SCT). Polymorphic peptides presented in HLA molecules, the …

Donor-recipient mismatch for common gene deletion polymorphisms in graft-versus-host disease

SA McCarroll, JE Bradner, H Turpeinen, L Volin… - Nature …, 2009 - nature.com
Transplantation and pregnancy, in which two diploid genomes reside in one body, can each
lead to diseases in which immune cells from one individual target antigens encoded in the …