Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they …

Hepatocellular carcinoma (HCC) is a prevalent disease with a progression that is modulated
by the immune system. Systemic therapy is used in the advanced stage and until 2017 …

Accumulating evidence suggests that a high tumour burden has a negative effect on
anticancer immunity. The concept of tumour burden, simply defined as the total amount of …

Neutrophils are expanded and abundant in cancer-bearing hosts. Under the influence of
CXCR1 and CXCR2 chemokine receptor agonists and other chemotactic factors produced …

Although elevated plasma interleukin-8 (pIL-8) has been associated with poor outcome to
immune checkpoint blockade, this has not been comprehensively evaluated in large …

Lung cancer is the leading cause of cancer-related death in the world. It is broadly divided
into small cell (SCLC, approx. 15% cases) and non-small cell lung cancer (NSCLC, approx …

Malignant gliomas are largely refractory to immune checkpoint blockade (ICB) therapy. To
explore the underlying immune regulators, we examine the microenvironment in glioma and …

The gut–liver axis plays a pivotal role in the pathogenesis of nonalcoholic fatty liver disease
(NAFLD), which is the third leading cause of hepatocellular carcinoma (HCC) worldwide …

Inhibition of the chemokine receptor CXCR4 in combination with blockade of the PD-1/PD-
L1 T cell checkpoint induces T cell infiltration and anticancer responses in murine and …

One of the most important mechanisms by which cancer fosters its own development is the
generation of an immune microenvironment that inhibits or impairs antitumor immune …